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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Author

Listed:
  • Mats Hellström

    (AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    and)

  • Li-Kun Phng

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK)

  • Jennifer J. Hofmann

    (Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA)

  • Elisabet Wallgard

    (AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    and)

  • Leigh Coultas

    (Program for Developmental Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Per Lindblom

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    Present addresses: Molecular Toxicology, Safety Assessment, AstraZeneca R&D, SE-151 85 Södertälje, Sweden (P.L.); Stem Cell Center, BMC B10, Klinikg. 26, Lund University, SE-221 84 Lund, Sweden (A.-K.N.); Department of Physiology, Göteborg University, P.O. Box 434, SE-405 30 Göteborg, Sweden (L.K.).)

  • Jackelyn Alva

    (Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA)

  • Ann-Katrin Nilsson

    (AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    Present addresses: Molecular Toxicology, Safety Assessment, AstraZeneca R&D, SE-151 85 Södertälje, Sweden (P.L.); Stem Cell Center, BMC B10, Klinikg. 26, Lund University, SE-221 84 Lund, Sweden (A.-K.N.); Department of Physiology, Göteborg University, P.O. Box 434, SE-405 30 Göteborg, Sweden (L.K.).)

  • Linda Karlsson

    (AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    Present addresses: Molecular Toxicology, Safety Assessment, AstraZeneca R&D, SE-151 85 Södertälje, Sweden (P.L.); Stem Cell Center, BMC B10, Klinikg. 26, Lund University, SE-221 84 Lund, Sweden (A.-K.N.); Department of Physiology, Göteborg University, P.O. Box 434, SE-405 30 Göteborg, Sweden (L.K.).)

  • Nicholas Gaiano

    (Neurology, Neuroscience and Oncology, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA)

  • Keejung Yoon

    (Neurology, Neuroscience and Oncology, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA)

  • Janet Rossant

    (Program for Developmental Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • M. Luisa Iruela-Arispe

    (Cell and Developmental Biology and Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA)

  • Mattias Kalén

    (AngioGenetics Sweden AB, Scheeles väg 2, SE-171 77 Stockholm, Sweden
    and)

  • Holger Gerhardt

    (Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK)

  • Christer Betsholtz

    (and
    Karolinska Institutet, SE 171 77 Stockholm, Sweden)

Abstract

One of two papers showing that delta-like 4/Notch signalling limits angiogenic sprouting and branching by regulating tip cell formation.

Suggested Citation

  • Mats Hellström & Li-Kun Phng & Jennifer J. Hofmann & Elisabet Wallgard & Leigh Coultas & Per Lindblom & Jackelyn Alva & Ann-Katrin Nilsson & Linda Karlsson & Nicholas Gaiano & Keejung Yoon & Janet Ros, 2007. "Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis," Nature, Nature, vol. 445(7129), pages 776-780, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7129:d:10.1038_nature05571
    DOI: 10.1038/nature05571
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    Citations

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    Cited by:

    1. Fuchun Yang & Shiva Kalantari & Banzhan Ruan & Shaogang Sun & Zhaoqun Bian & Jun-Lin Guan, 2023. "Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Rocío Vega & Manuel Carretero & Rui D M Travasso & Luis L Bonilla, 2020. "Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model," PLOS Computational Biology, Public Library of Science, vol. 16(1), pages 1-31, January.
    3. Eun-A Kwak & Christopher C. Pan & Aaron Ramonett & Sanjay Kumar & Paola Cruz-Flores & Tasmia Ahmed & Hannah R. Ortiz & Jeffrey J. Lochhead & Nathan A. Ellis & Ghassan Mouneimne & Teodora G. Georgieva , 2022. "βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Yassine El Bakkouri & Rony Chidiac & Chantal Delisle & Jeanne Corriveau & Gael Cagnone & Vanda Gaonac’h-Lovejoy & Ashley Chin & Éric Lécuyer & Stephane Angers & Jean-Sébastien Joyal & Ivan Topisirovic, 2024. "ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Rui D M Travasso & Eugenia Corvera Poiré & Mario Castro & Juan Carlos Rodrguez-Manzaneque & A Hernández-Machado, 2011. "Tumor Angiogenesis and Vascular Patterning: A Mathematical Model," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.

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