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Phosphoinositides in cell regulation and membrane dynamics

Author

Listed:
  • Gilbert Di Paolo

    (The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center)

  • Pietro De Camilli

    (Neurodegeneration and Repair, Howard Hughes Medical Institute and Kavli Institute for Neuroscience, Yale University School of Medicine)

Abstract

Inositol phospholipids have long been known to have an important regulatory role in cell physiology. The repertoire of cellular processes known to be directly or indirectly controlled by this class of lipids has now dramatically expanded. Through interactions mediated by their headgroups, which can be reversibly phosphorylated to generate seven species, phosphoinositides play a fundamental part in controlling membrane–cytosol interfaces. These lipids mediate acute responses, but also act as constitutive signals that help define organelle identity. Their functions, besides classical signal transduction at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and the permeability and transport functions of membranes.

Suggested Citation

  • Gilbert Di Paolo & Pietro De Camilli, 2006. "Phosphoinositides in cell regulation and membrane dynamics," Nature, Nature, vol. 443(7112), pages 651-657, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7112:d:10.1038_nature05185
    DOI: 10.1038/nature05185
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    1. Salome Funes & Jonathan Jung & Del Hayden Gadd & Michelle Mosqueda & Jianjun Zhong & Shankaracharya & Matthew Unger & Karly Stallworth & Debra Cameron & Melissa S. Rotunno & Pepper Dawes & Megan Fowle, 2024. "Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    2. Yu-Te Yeh & Chandan Sona & Xin Yan & Yunxiao Li & Adrija Pathak & Mark I. McDermott & Zhigang Xie & Liangwen Liu & Anoop Arunagiri & Yuting Wang & Amaury Cazenave-Gassiot & Adhideb Ghosh & Ferdinand v, 2023. "Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Yue Huang & Ruipeng Mu & David Wen & Joseph S Grimsby & Meina Liang & Anton I Rosenbaum, 2021. "Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-14, June.
    4. Seiichi Koike & Reinhard Jahn, 2024. "Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Di-Ao Liu & Kai Tao & Bin Wu & Ziyan Yu & Malwina Szczepaniak & Matthew Rames & Changsong Yang & Tatyana Svitkina & Yueyao Zhu & Fengyuan Xu & Xiaolin Nan & Wei Guo, 2023. "A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Antonio L Egea-Jiménez & Ángel Pérez-Lara & Senena Corbalán-García & Juan C Gómez-Fernández, 2013. "Phosphatidylinositol 4,5-Bisphosphate Decreases the Concentration of Ca2+, Phosphatidylserine and Diacylglycerol Required for Protein Kinase C α to Reach Maximum Activity," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
    7. Nilmani Singh & Adriana Reyes-Ordoñez & Michael A. Compagnone & Jesus F. Moreno & Benjamin J. Leslie & Taekjip Ha & Jie Chen, 2021. "Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    8. Maria Thürmer & André Gollowitzer & Helmut Pein & Konstantin Neukirch & Elif Gelmez & Lorenz Waltl & Natalie Wielsch & René Winkler & Konstantin Löser & Julia Grander & Madlen Hotze & Sönke Harder & A, 2022. "PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    9. Ying Huang & Chenyang Xue & Ruiqian Bu & Cang Wu & Jiachen Li & Jinqiu Zhang & Jinyu Chen & Zhaoying Shi & Yonglong Chen & Yong Wang & Zhongmin Liu, 2024. "Inhibition and transport mechanisms of the ABC transporter hMRP5," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    10. Darshini Jeyasimman & Bilge Ercan & Dennis Dharmawan & Tomoki Naito & Jingbo Sun & Yasunori Saheki, 2021. "PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

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