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hERG potassium channels and cardiac arrhythmia

Author

Listed:
  • Michael C. Sanguinetti

    (University of Utah)

  • Martin Tristani-Firouzi

    (Nora Eccles Harrison Cardiovascular Research & Training Institute, University of Utah
    University of Utah)

Abstract

hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to life-threatening arrhythmias. Arrhythmia can also be induced by a blockage of hERG channels by a surprisingly diverse group of drugs. This side effect is a common reason for drug failure in preclinical safety trials. Insights gained from the crystal structures of other potassium channels have helped our understanding of the block of hERG channels and the mechanisms of gating.

Suggested Citation

  • Michael C. Sanguinetti & Martin Tristani-Firouzi, 2006. "hERG potassium channels and cardiac arrhythmia," Nature, Nature, vol. 440(7083), pages 463-469, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7083:d:10.1038_nature04710
    DOI: 10.1038/nature04710
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    Cited by:

    1. Joshua Mayourian & Ruben M Savizky & Eric A Sobie & Kevin D Costa, 2016. "Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes," PLOS Computational Biology, Public Library of Science, vol. 12(7), pages 1-29, July.
    2. Moniruzzaman & Mohammed Jabedul Hoque & Mohammad Nasir Uddin & Amrin Ahsan & Tareq Mahmud, 2018. "Quantum Chemical, Molecular Docking, and ADMET Predictions of Ketorolac and its Modified Analogues," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8723-8729, December.
    3. Fang Du & Joseph J Babcock & Haibo Yu & Beiyan Zou & Min Li, 2015. "Global Analysis Reveals Families of Chemical Motifs Enriched for hERG Inhibitors," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-21, February.
    4. Amrita X Sarkar & Eric A Sobie, 2010. "Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells," PLOS Computational Biology, Public Library of Science, vol. 6(9), pages 1-11, September.
    5. Dahai Yu & Lin Lv & Li Fang & Bo Zhang & Junnan Wang & Ge Zhan & Lei Zhao & Xin Zhao & Baoxin Li, 2017. "Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-19, August.
    6. Moniruzzaman & Mohammed Jabedul Hoque & Amrin Ahsan & Md Belayet Hossain, 2018. "Molecular Docking, Pharmacokinetic, and DFT Calculation of Naproxen and its Degradants," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 9(5), pages 7360-7365, October.
    7. Haiyan Mao & Xiaoli Lu & Justin Michael Karush & Xiaoyan Huang & Xi Yang & Yanna Ba & Ying Wang & Ningsheng Liu & Jianqing Zhou & Jiangfang Lian, 2013. "Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-12, June.
    8. Bryan Cernuda & Christopher Thomas Fernandes & Salma Mohamed Allam & Matthew Orzillo & Gabrielle Suppa & Zuleen Chia Chang & Demosthenes Athanasopoulos & Zafir Buraei, 2019. "The molecular determinants of R-roscovitine block of hERG channels," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-26, September.
    9. Carlos A. Z. Bassetto & Flavio Costa & Carlo Guardiani & Francisco Bezanilla & Alberto Giacomello, 2023. "Noncanonical electromechanical coupling paths in cardiac hERG potassium channel," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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