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Mapping determinants of human gene expression by regional and genome-wide association

Author

Listed:
  • Vivian G. Cheung

    (University of Pennsylvania
    University of Pennsylvania
    The Children's Hospital of Philadelphia)

  • Richard S. Spielman

    (University of Pennsylvania)

  • Kathryn G. Ewens

    (University of Pennsylvania)

  • Teresa M. Weber

    (University of Pennsylvania
    The Children's Hospital of Philadelphia)

  • Michael Morley

    (The Children's Hospital of Philadelphia)

  • Joshua T. Burdick

    (The Children's Hospital of Philadelphia)

Abstract

Self expression Even when two humans have the same genes, the levels at which those genes are expressed can contribute greatly to variation between individuals. Based on HapMap Project data, Cheung et al. use genetic association to map the parts of each gene that control levels of expression. The data also provide a detailed comparison of the techniques of genetic linkage and association, both of which are used to look for genetic determinants of human disease.

Suggested Citation

  • Vivian G. Cheung & Richard S. Spielman & Kathryn G. Ewens & Teresa M. Weber & Michael Morley & Joshua T. Burdick, 2005. "Mapping determinants of human gene expression by regional and genome-wide association," Nature, Nature, vol. 437(7063), pages 1365-1369, October.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7063:d:10.1038_nature04244
    DOI: 10.1038/nature04244
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    Cited by:

    1. Jae Hoon Sul & Buhm Han & Chun Ye & Ted Choi & Eleazar Eskin, 2013. "Effectively Identifying eQTLs from Multiple Tissues by Combining Mixed Model and Meta-analytic Approaches," PLOS Genetics, Public Library of Science, vol. 9(6), pages 1-13, June.
    2. Jin Hyun Ju & Sushila A Shenoy & Ronald G Crystal & Jason G Mezey, 2017. "An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci," PLOS Computational Biology, Public Library of Science, vol. 13(5), pages 1-26, May.
    3. Josine L Min & Jennifer M Taylor & J Brent Richards & Tim Watts & Fredrik H Pettersson & John Broxholme & Kourosh R Ahmadi & Gabriela L Surdulescu & Ernesto Lowy & Christian Gieger & Chris Newton-Cheh, 2011. "The Use of Genome-Wide eQTL Associations in Lymphoblastoid Cell Lines to Identify Novel Genetic Pathways Involved in Complex Traits," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-14, July.
    4. Heather E Wheeler & Kaanan P Shah & Jonathon Brenner & Tzintzuni Garcia & Keston Aquino-Michaels & GTEx Consortium & Nancy J Cox & Dan L Nicolae & Hae Kyung Im, 2016. "Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues," PLOS Genetics, Public Library of Science, vol. 12(11), pages 1-23, November.
    5. Yixin Fang & Yang Feng & Ming Yuan, 2014. "Regularized principal components of heritability," Computational Statistics, Springer, vol. 29(3), pages 455-465, June.
    6. Alexandra C Nica & Leopold Parts & Daniel Glass & James Nisbet & Amy Barrett & Magdalena Sekowska & Mary Travers & Simon Potter & Elin Grundberg & Kerrin Small & Åsa K Hedman & Veronique Bataille & Jo, 2011. "The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study," PLOS Genetics, Public Library of Science, vol. 7(2), pages 1-9, February.
    7. David M Evans & Marie Jo A Brion & Lavinia Paternoster & John P Kemp & George McMahon & Marcus Munafò & John B Whitfield & Sarah E Medland & Grant W Montgomery & The GIANT consortium & The CRP consort, 2013. "Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates," PLOS Genetics, Public Library of Science, vol. 9(10), pages 1-15, October.
    8. Hui-Min Wang & Ching-Lin Hsiao & Ai-Ru Hsieh & Ying-Chao Lin & Cathy S J Fann, 2012. "Constructing Endophenotypes of Complex Diseases Using Non-Negative Matrix Factorization and Adjusted Rand Index," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-12, July.
    9. Barbara E Stranger & Stephen B Montgomery & Antigone S Dimas & Leopold Parts & Oliver Stegle & Catherine E Ingle & Magda Sekowska & George Davey Smith & David Evans & Maria Gutierrez-Arcelus & Alkes P, 2012. "Patterns of Cis Regulatory Variation in Diverse Human Populations," PLOS Genetics, Public Library of Science, vol. 8(4), pages 1-13, April.
    10. Ning Jiang & Minghui Wang & Tianye Jia & Lin Wang & Lindsey Leach & Christine Hackett & David Marshall & Zewei Luo, 2011. "A Robust Statistical Method for Association-Based eQTL Analysis," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-11, August.
    11. Rudi Alberts & Peter Terpstra & Yang Li & Rainer Breitling & Jan-Peter Nap & Ritsert C Jansen, 2007. "Sequence Polymorphisms Cause Many False cis eQTLs," PLOS ONE, Public Library of Science, vol. 2(7), pages 1-5, July.
    12. Ryan Abo & Gregory D Jenkins & Liewei Wang & Brooke L Fridley, 2012. "Identifying the Genetic Variation of Gene Expression Using Gene Sets: Application of Novel Gene Set eQTL Approach to PharmGKB and KEGG," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-11, August.
    13. Paul C Boutros & Ivy D Moffat & Allan B Okey & Raimo Pohjanvirta, 2011. "mRNA Levels in Control Rat Liver Display Strain-Specific, Hereditary, and AHR-Dependent Components," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-15, July.
    14. Daria V Zhernakova & Eleonora de Klerk & Harm-Jan Westra & Anastasios Mastrokolias & Shoaib Amini & Yavuz Ariyurek & Rick Jansen & Brenda W Penninx & Jouke J Hottenga & Gonneke Willemsen & Eco J de Ge, 2013. "DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts," PLOS Genetics, Public Library of Science, vol. 9(6), pages 1-15, June.

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