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The genome sequence of the rice blast fungus Magnaporthe grisea

Author

Listed:
  • Ralph A. Dean

    (North Carolina State University)

  • Nicholas J. Talbot

    (University of Exeter, Washington Singer Laboratories)

  • Daniel J. Ebbole

    (Texas A&M University)

  • Mark L. Farman

    (University of Kentucky)

  • Thomas K. Mitchell

    (North Carolina State University)

  • Marc J. Orbach

    (University of Arizona)

  • Michael Thon

    (Texas A&M University)

  • Resham Kulkarni

    (North Carolina State University
    RTI International, Research Triangle Park)

  • Jin-Rong Xu

    (Purdue University)

  • Huaqin Pan

    (North Carolina State University)

  • Nick D. Read

    (University of Edinburgh)

  • Yong-Hwan Lee

    (Seoul National University)

  • Ignazio Carbone

    (North Carolina State University)

  • Doug Brown

    (North Carolina State University)

  • Yeon Yee Oh

    (North Carolina State University)

  • Nicole Donofrio

    (North Carolina State University)

  • Jun Seop Jeong

    (North Carolina State University)

  • Darren M. Soanes

    (University of Exeter, Washington Singer Laboratories)

  • Slavica Djonovic

    (Texas A&M University)

  • Elena Kolomiets

    (Texas A&M University)

  • Cathryn Rehmeyer

    (University of Kentucky)

  • Weixi Li

    (University of Kentucky)

  • Michael Harding

    (University of Arizona)

  • Soonok Kim

    (Seoul National University)

  • Marc-Henri Lebrun

    (Bayer Cropscience)

  • Heidi Bohnert

    (Bayer Cropscience)

  • Sean Coughlan

    (Agilent Technologies)

  • Jonathan Butler

    (Broad Institute of MIT and Harvard)

  • Sarah Calvo

    (Broad Institute of MIT and Harvard)

  • Li-Jun Ma

    (Broad Institute of MIT and Harvard)

  • Robert Nicol

    (Broad Institute of MIT and Harvard)

  • Seth Purcell

    (Broad Institute of MIT and Harvard)

  • Chad Nusbaum

    (Broad Institute of MIT and Harvard)

  • James E. Galagan

    (Broad Institute of MIT and Harvard)

  • Bruce W. Birren

    (Broad Institute of MIT and Harvard)

Abstract

Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.

Suggested Citation

  • Ralph A. Dean & Nicholas J. Talbot & Daniel J. Ebbole & Mark L. Farman & Thomas K. Mitchell & Marc J. Orbach & Michael Thon & Resham Kulkarni & Jin-Rong Xu & Huaqin Pan & Nick D. Read & Yong-Hwan Lee , 2005. "The genome sequence of the rice blast fungus Magnaporthe grisea," Nature, Nature, vol. 434(7036), pages 980-986, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7036:d:10.1038_nature03449
    DOI: 10.1038/nature03449
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    Cited by:

    1. Gang Li & Ziwen Gong & Nawaraj Dulal & Margarita Marroquin-Guzman & Raquel O. Rocha & Michael Richter & Richard A. Wilson, 2023. "A protein kinase coordinates cycles of autophagy and glutaminolysis in invasive hyphae of the fungus Magnaporthe oryzae within rice cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Yogesh K. Gupta & Francismar C. Marcelino-Guimarães & Cécile Lorrain & Andrew Farmer & Sajeet Haridas & Everton Geraldo Capote Ferreira & Valéria S. Lopes-Caitar & Liliane Santana Oliveira & Emmanuell, 2023. "Major proliferation of transposable elements shaped the genome of the soybean rust pathogen Phakopsora pachyrhizi," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Jun Huang & David Rowe & Pratima Subedi & Wei Zhang & Tyler Suelter & Barbara Valent & David E. Cook, 2022. "CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Hang Liu & Xunli Lu & Mengfei Li & Zhiqin Lun & Xia Yan & Changfa Yin & Guixin Yuan & Xingbin Wang & Ning Liu & Di Liu & Mian Wu & Ziluolong Luo & Yan Zhang & Vijai Bhadauria & Jun Yang & Nicholas J. , 2023. "Plant immunity suppression by an exo-β-1,3-glucanase and an elongation factor 1α of the rice blast fungus," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Xuetao Shi & Xin Xie & Yuanwen Guo & Junqi Zhang & Ziwen Gong & Kai Zhang & Jie Mei & Xinyao Xia & Haoxue Xia & Na Ning & Yutao Xiao & Qing Yang & Guo-Liang Wang & Wende Liu, 2024. "A fungal core effector exploits the OsPUX8B.2–OsCDC48-6 module to suppress plant immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Md Azadul Haque & Mohd Y. Rafii & Martini Mohammad Yusoff & Nusaibah Syd Ali & Oladosu Yusuff & Debi Rani Datta & Mohammad Anisuzzaman & Mohammad Ferdous Ikbal, 2021. "Recent Advances in Rice Varietal Development for Durable Resistance to Biotic and Abiotic Stresses through Marker-Assisted Gene Pyramiding," Sustainability, MDPI, vol. 13(19), pages 1-25, September.
    7. Jongchan Woo & Seungmee Jung & Seongbeom Kim & Yurong Li & Hyunjung Chung & Tatiana V. Roubtsova & Honghong Zhang & Celine Caseys & Dan Kliebenstein & Kyung-Nam Kim & Richard M. Bostock & Yong-Hwan Le, 2024. "Attenuation of phytofungal pathogenicity of Ascomycota by autophagy modulators," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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