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Targeted cancer therapy

Author

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  • Charles Sawyers

    (Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center)

Abstract

Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progress in understanding the molecular changes that underlie cancer development offer the prospect of specifically targeting malfunctioning molecules and pathways to achieve more effective and rational cancer therapy.

Suggested Citation

  • Charles Sawyers, 2004. "Targeted cancer therapy," Nature, Nature, vol. 432(7015), pages 294-297, November.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7015:d:10.1038_nature03095
    DOI: 10.1038/nature03095
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    Cited by:

    1. Noriyuki Uchida & Ai Kohata & Kou Okuro & Annalisa Cardellini & Chiara Lionello & Eric A. Zizzi & Marco A. Deriu & Giovanni M. Pavan & Michio Tomishige & Takaaki Hikima & Takuzo Aida, 2022. "Reconstitution of microtubule into GTP-responsive nanocapsules," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jacob D Feala & Jorge Cortes & Phillip M Duxbury & Andrew D McCulloch & Carlo Piermarocchi & Giovanni Paternostro, 2012. "Statistical Properties and Robustness of Biological Controller-Target Networks," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-11, January.
    3. Wei-Xiang Qi & Yu-Jing Huang & Yang Yao & Zan Shen & Da-Liu Min, 2013. "Incidence and Risk of Treatment-Related Mortality with mTOR Inhibitors Everolimus and Temsirolimus in Cancer Patients: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    4. Yan Han & Ying Yuan & Sha Cao & Muyi Li & Yong Zang, 2020. "On the Use of Marker Strategy Design to Detect Predictive Marker Effect in Cancer Immunotherapy and Targeted Therapy," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(2), pages 180-195, July.
    5. Yi Fu & Robert Kunz & Jianhua Wu & Cheng Dong, 2012. "Study of Local Hydrodynamic Environment in Cell-Substrate Adhesion Using Side-View μPIV Technology," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-13, February.

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