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Mechanisms of gene silencing by double-stranded RNA

Author

Listed:
  • Gunter Meister

    (Laboratory of RNA Molecular Biology, The Rockefeller University)

  • Thomas Tuschl

    (Laboratory of RNA Molecular Biology, The Rockefeller University)

Abstract

Double-stranded RNA (dsRNA) is an important regulator of gene expression in many eukaryotes. It triggers different types of gene silencing that are collectively referred to as RNA silencing or RNA interference. A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure. These short dsRNAs guide RNA silencing by specific and distinct mechanisms. Many components of the RNA silencing machinery still need to be identified and characterized, but a more complete understanding of the process is imminent.

Suggested Citation

  • Gunter Meister & Thomas Tuschl, 2004. "Mechanisms of gene silencing by double-stranded RNA," Nature, Nature, vol. 431(7006), pages 343-349, September.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7006:d:10.1038_nature02873
    DOI: 10.1038/nature02873
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    Cited by:

    1. Lei Li & Yu-Tian Wang & Cun-Mei Ji & Chun-Hou Zheng & Jian-Cheng Ni & Yan-Sen Su, 2021. "GCAEMDA: Predicting miRNA-disease associations via graph convolutional autoencoder," PLOS Computational Biology, Public Library of Science, vol. 17(12), pages 1-19, December.
    2. J. Fulneček, 2007. "Isolation and detection of small RNA molecules," Plant, Soil and Environment, Czech Academy of Agricultural Sciences, vol. 53(10), pages 451-455.
    3. Zhen Shen & You-Hua Zhang & Kyungsook Han & Asoke K. Nandi & Barry Honig & De-Shuang Huang, 2017. "miRNA-Disease Association Prediction with Collaborative Matrix Factorization," Complexity, Hindawi, vol. 2017, pages 1-9, September.
    4. Thuc Duy Le & Junpeng Zhang & Lin Liu & Jiuyong Li, 2015. "Ensemble Methods for MiRNA Target Prediction from Expression Data," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-19, June.
    5. Arnaud Segers & Joachim Carpentier & Frédéric Francis & Rudy Caparros Megido, 2023. "Gene Silencing of laccase 1 Induced by Double-Stranded RNA in Callosobruchus maculatus (Fabricius 1775) (Coleoptera: Chrysomelidae) Suggests RNAi as a Potential New Biotechnological Tool for Bruchid’s," Agriculture, MDPI, vol. 13(2), pages 1-19, February.
    6. Xing Chen & Jun Yin & Jia Qu & Li Huang, 2018. "MDHGI: Matrix Decomposition and Heterogeneous Graph Inference for miRNA-disease association prediction," PLOS Computational Biology, Public Library of Science, vol. 14(8), pages 1-24, August.
    7. Jun Meng & Lin Shi & Yushi Luan, 2014. "Plant microRNA-Target Interaction Identification Model Based on the Integration of Prediction Tools and Support Vector Machine," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-12, July.
    8. Xing Chen & Li Huang, 2017. "LRSSLMDA: Laplacian Regularized Sparse Subspace Learning for MiRNA-Disease Association prediction," PLOS Computational Biology, Public Library of Science, vol. 13(12), pages 1-28, December.
    9. Emilie Estrabaud & Kevin Appourchaux & Ivan Bièche & Fabrice Carrat & Martine Lapalus & Olivier Lada & Michelle Martinot-Peignoux & Nathalie Boyer & Patrick Marcellin & Michel Vidaud & Tarik Asselah, 2015. "IFI35, mir-99a and HCV Genotype to Predict Sustained Virological Response to Pegylated-Interferon Plus Ribavirin in Chronic Hepatitis C," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-19, April.

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