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Evolving concepts of rheumatoid arthritis

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  • Gary S. Firestein

    (Allergy and Immunology, School of Medicine, University of California)

Abstract

Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of disability. It existed in early Native American populations several thousand years ago but might not have appeared in Europe until the 17th century. Early theories on the pathogenesis of rheumatoid arthritis focused on autoantibodies and immune complexes. T-cell-mediated antigen-specific responses, T-cell-independent cytokine networks, and aggressive tumour-like behaviour of rheumatoid synovium have also been implicated. More recently, the contribution of autoantibodies has returned to the forefront. Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis.

Suggested Citation

  • Gary S. Firestein, 2003. "Evolving concepts of rheumatoid arthritis," Nature, Nature, vol. 423(6937), pages 356-361, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6937:d:10.1038_nature01661
    DOI: 10.1038/nature01661
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    1. Chikashi Terao & Koichiro Ohmura & Katsunori Ikari & Yuta Kochi & Etsuko Maruya & Masaki Katayama & Kimiko Yurugi & Kota Shimada & Akira Murasawa & Shigeru Honjo & Kiyoshi Takasugi & Keitaro Matsuo & , 2012. "ACPA-Negative RA Consists of Two Genetically Distinct Subsets Based on RF Positivity in Japanese," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
    2. Leena R Baghdadi & Richard J Woodman & E Michael Shanahan & Arduino A Mangoni, 2015. "The Impact of Traditional Cardiovascular Risk Factors on Cardiovascular Outcomes in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-18, February.
    3. Bahman Razi & Samira Esmaeili Reykandeh & Shahab Alizadeh & AliAkbar Amirzargar & Amene Saghazadeh & Nima Rezaei, 2019. "TIM family gene polymorphism and susceptibility to rheumatoid arthritis: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-15, February.
    4. Hyemin Jeong & Young-Soo Chang & Sun Young Baek & Seon Woo Kim & Yeong Hee Eun & In Young Kim & Jaejoon Lee & Eun-Mi Koh & Hoon-Suk Cha, 2016. "Evaluation of Audiometric Test Results to Determine Hearing Impairment in Patients with Rheumatoid Arthritis: Analysis of Data from the Korean National Health and Nutrition Examination Survey," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-14, October.
    5. Pushplata Prasad & Ashok Kumar & Rajiva Gupta & Ramesh C Juyal & Thelma B. K., 2012. "Caucasian and Asian Specific Rheumatoid Arthritis Risk Loci Reveal Limited Replication and Apparent Allelic Heterogeneity in North Indians," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-5, February.
    6. Antonio Julià & Alba Erra & Carles Palacio & Carlos Tomas & Xavier Sans & Pere Barceló & Sara Marsal, 2009. "An Eight-Gene Blood Expression Profile Predicts the Response to Infliximab in Rheumatoid Arthritis," PLOS ONE, Public Library of Science, vol. 4(10), pages 1-8, October.
    7. Ishraq Abdul Ameer Salih* & Rabab Omran, 2018. "The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 4(10), pages 76-79, 10-2018.
    8. Kelei Li & Tao Huang & Jusheng Zheng & Kejian Wu & Duo Li, 2014. "Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on C-Reactive Protein, Interleukin 6 and Tumor Necrosis Factor α: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-1, February.
    9. Jiajing Jiang & Kelei Li & Fenglei Wang & Bo Yang & Yuanqing Fu & Jusheng Zheng & Duo Li, 2016. "Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-18, January.
    10. Chikashi Terao & Motomu Hashimoto & Keiichi Yamamoto & Kosaku Murakami & Koichiro Ohmura & Ran Nakashima & Noriyuki Yamakawa & Hajime Yoshifuji & Naoichiro Yukawa & Daisuke Kawabata & Takashi Usui & H, 2013. "Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis – Analysis Using More than 17,000 Assessments in the KURAMA Database," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-6, March.
    11. Haobo Han & Jiakai Xing & Wenqi Chen & Jiaxin Jia & Quanshun Li, 2023. "Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis in rats," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    12. Chikashi Terao & Koichiro Ohmura & Masaki Katayama & Meiko Takahashi & Miki Kokubo & Gora Diop & Yoshinobu Toda & Natsuki Yamamoto & Human Disease Genomics Working Group & Rheumatoid Arthritis (RA) Cl, 2011. "Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis—A Genome-Wide Study Combined with Immunological Analyses," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-10, June.
    13. Chi Ching Chang & Chi Sheng Chiou & Hsiu Li Lin & Li Hsuan Wang & Yu Sheng Chang & Hsiu-Chen Lin, 2015. "Increased Risk of Acute Pancreatitis in Patients with Rheumatoid Arthritis: A Population-Based Cohort Study," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-11, August.

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