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The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population

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  • Ishraq Abdul Ameer Salih*

    (Department of Biology,Science ForWomen, University of Babylon, Iraq)

  • Rabab Omran

    (Department of Biology,Science , University of Babylon. Iraq)

Abstract

Rheumatoid Arthritis (RA) has been the most disease that recorded high number in Iraqi population, Interleukin-4 (IL-4) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); which it is role of IL-4 genetic polymorphisms in RA. Method: A total of 50 unrelated IRAQ patients with RA and 40 healthy Iraqi volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T  polymorphisms were genotyped gene polymorphism implemented used RFLP technique. Result:The results show The genotype distributions and allele frequencies of IL-4-590 C/T  polymorphisms in RA patients were significantly different from healthy Statistically significant differences were observed in genotypes for IL-4-590 .The frequencies of the T allele on the IL- 4-590 were significantly increased in RA patients. Conclusion. The IL-4-590  promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Iraqi.

Suggested Citation

  • Ishraq Abdul Ameer Salih* & Rabab Omran, 2018. "The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population," Journal of Biotechnology Research, Academic Research Publishing Group, vol. 4(10), pages 76-79, 10-2018.
    • Handle: RePEc:arp:rjbarp:2018:p:76-79
    DOI: 10.32861/jbr.410.76.79
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    References listed on IDEAS

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    1. Gary S. Firestein, 2003. "Evolving concepts of rheumatoid arthritis," Nature, Nature, vol. 423(6937), pages 356-361, May.
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