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Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis—A Genome-Wide Study Combined with Immunological Analyses

Author

Listed:
  • Chikashi Terao
  • Koichiro Ohmura
  • Masaki Katayama
  • Meiko Takahashi
  • Miki Kokubo
  • Gora Diop
  • Yoshinobu Toda
  • Natsuki Yamamoto
  • Human Disease Genomics Working Group
  • Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium
  • Reiko Shinkura
  • Masakazu Shimizu
  • Ivo Gut
  • Simon Heath
  • Inga Melchers
  • Toshiaki Manabe
  • Mark Lathrop
  • Tsuneyo Mimori
  • Ryo Yamada
  • Fumihiko Matsuda

Abstract

Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study of RA in Japanese using 225,079 SNPs genotyped in 990 cases and 1,236 controls from two independent collections (658 cases and 934 controls in collection1; 332 cases and 302 controls in collection2), followed by replication studies in two additional collections (874 cases and 855 controls in collection3; 1,264 cases and 948 controls in collection4). SNPs showing p

Suggested Citation

  • Chikashi Terao & Koichiro Ohmura & Masaki Katayama & Meiko Takahashi & Miki Kokubo & Gora Diop & Yoshinobu Toda & Natsuki Yamamoto & Human Disease Genomics Working Group & Rheumatoid Arthritis (RA) Cl, 2011. "Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis—A Genome-Wide Study Combined with Immunological Analyses," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0020457
    DOI: 10.1371/journal.pone.0020457
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    References listed on IDEAS

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    1. Gary S. Firestein, 2003. "Evolving concepts of rheumatoid arthritis," Nature, Nature, vol. 423(6937), pages 356-361, May.
    2. B. Devlin & Kathryn Roeder, 1999. "Genomic Control for Association Studies," Biometrics, The International Biometric Society, vol. 55(4), pages 997-1004, December.
    3. Hideo Nakanishi & Ryo Yamada & Norimoto Gotoh & Hisako Hayashi & Kenji Yamashiro & Noriaki Shimada & Kyoko Ohno-Matsui & Manabu Mochizuki & Masaaki Saito & Tomohiro Iida & Keitaro Matsuo & Kazuo Tajim, 2009. "A Genome-Wide Association Analysis Identified a Novel Susceptible Locus for Pathological Myopia at 11q24.1," PLOS Genetics, Public Library of Science, vol. 5(9), pages 1-7, September.
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    1. Chikashi Terao & Koichiro Ohmura & Katsunori Ikari & Yuta Kochi & Etsuko Maruya & Masaki Katayama & Kimiko Yurugi & Kota Shimada & Akira Murasawa & Shigeru Honjo & Kiyoshi Takasugi & Keitaro Matsuo & , 2012. "ACPA-Negative RA Consists of Two Genetically Distinct Subsets Based on RF Positivity in Japanese," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.

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