IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v416y2002i6880d10.1038_416531a.html
   My bibliography  Save this article

The cost of inbreeding in Arabidopsis

Author

Listed:
  • Carlos D. Bustamante

    (Harvard University
    University of Oxford)

  • Rasmus Nielsen

    (Cornell University)

  • Stanley A. Sawyer

    (Washington University)

  • Kenneth M. Olsen

    (North Carolina State University)

  • Michael D. Purugganan

    (North Carolina State University)

  • Daniel L. Hartl

    (Harvard University)

Abstract

Population geneticists have long sought to estimate the distribution of selection intensities among genes of diverse function across the genome. Only recently have DNA sequencing and analytical techniques converged to make this possible. Important advances have come from comparing genetic variation within species (polymorphism) with fixed differences between species (divergence)1,2. These approaches have been used to examine individual genes for evidence of selection. Here we use the fact that the time since species divergence allows combination of data across genes. In a comparison of amino-acid replacements among species of the mustard weed Arabidopsis with those among species of the fruitfly Drosophila, we find evidence for predominantly beneficial gene substitutions in Drosophila but predominantly detrimental substitutions in Arabidopsis. We attribute this difference to the Arabidopsis mating system of partial self-fertilization, which corroborates a prediction of population genetics theory3,4,5,6 that species with a high frequency of inbreeding are less efficient in eliminating deleterious mutations owing to their reduced effective population size.

Suggested Citation

  • Carlos D. Bustamante & Rasmus Nielsen & Stanley A. Sawyer & Kenneth M. Olsen & Michael D. Purugganan & Daniel L. Hartl, 2002. "The cost of inbreeding in Arabidopsis," Nature, Nature, vol. 416(6880), pages 531-534, April.
  • Handle: RePEc:nat:nature:v:416:y:2002:i:6880:d:10.1038_416531a
    DOI: 10.1038/416531a
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/416531a
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/416531a?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Benger, Etam & Sella, Guy, 2013. "Modeling the effect of changing selective pressures on polymorphism and divergence," Theoretical Population Biology, Elsevier, vol. 85(C), pages 73-85.
    2. Amei Amei & Stanley Sawyer, 2012. "Statistical Inference of Selection and Divergence from a Time-Dependent Poisson Random Field Model," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    3. Rachel A Myers & Ferran Casals & Julie Gauthier & Fadi F Hamdan & Jon Keebler & Adam R Boyko & Carlos D Bustamante & Amelie M Piton & Dan Spiegelman & Edouard Henrion & Martine Zilversmit & Julie Huss, 2011. "A Population Genetic Approach to Mapping Neurological Disorder Genes Using Deep Resequencing," PLOS Genetics, Public Library of Science, vol. 7(2), pages 1-10, February.
    4. RoyChoudhury, Arindam & Wakeley, John, 2010. "Sufficiency of the number of segregating sites in the limit under finite-sites mutation," Theoretical Population Biology, Elsevier, vol. 78(2), pages 118-122.
    5. Kirsten E Eilertson & James G Booth & Carlos D Bustamante, 2012. "SnIPRE: Selection Inference Using a Poisson Random Effects Model," PLOS Computational Biology, Public Library of Science, vol. 8(12), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:416:y:2002:i:6880:d:10.1038_416531a. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.