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MAP kinase signalling cascade in Arabidopsis innate immunity

Author

Listed:
  • Tsuneaki Asai

    (Harvard Medical School, Massachusetts General Hospital)

  • Guillaume Tena

    (Harvard Medical School, Massachusetts General Hospital)

  • Joulia Plotnikova

    (Harvard Medical School, Massachusetts General Hospital)

  • Matthew R. Willmann

    (Harvard Medical School, Massachusetts General Hospital)

  • Wan-Ling Chiu

    (Harvard Medical School, Massachusetts General Hospital)

  • Lourdes Gomez-Gomez

    (Instituto de Desarrollo Regional, Sección de Biotecnología, Campus Universitario s/n)

  • Thomas Boller

    (Friedrich Miescher-Institute)

  • Frederick M. Ausubel

    (Harvard Medical School, Massachusetts General Hospital)

  • Jen Sheen

    (Harvard Medical School, Massachusetts General Hospital)

Abstract

There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.

Suggested Citation

  • Tsuneaki Asai & Guillaume Tena & Joulia Plotnikova & Matthew R. Willmann & Wan-Ling Chiu & Lourdes Gomez-Gomez & Thomas Boller & Frederick M. Ausubel & Jen Sheen, 2002. "MAP kinase signalling cascade in Arabidopsis innate immunity," Nature, Nature, vol. 415(6875), pages 977-983, February.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6875:d:10.1038_415977a
    DOI: 10.1038/415977a
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    Cited by:

    1. Jiaojiao Bai & Yuanyuan Zhou & Jianhang Sun & Kexin Chen & Yufang Han & Ranran Wang & Yanmin Zou & Mingshuo Du & Dongping Lu, 2023. "BIK1 protein homeostasis is maintained by the interplay of different ubiquitin ligases in immune signaling," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Vidhyavathi Raman & Clemencia M. Rojas & Balaji Vasudevan & Kevin Dunning & Jaydeep Kolape & Sunhee Oh & Jianfei Yun & Lishan Yang & Guangming Li & Bikram D. Pant & Qingzhen Jiang & Kirankumar S. Myso, 2022. "Agrobacterium expressing a type III secretion system delivers Pseudomonas effectors into plant cells to enhance transformation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Li Lin & Xingrui Zhang & Jialin Fan & Jiawei Li & Sichao Ren & Xin Gu & Panpan Li & Meiling Xu & Jingyi Xu & Wenjing Lei & Dongxiao Liu & Qinfu Sun & Guangqin Cai & Qing-Yong Yang & Youping Wang & Jia, 2024. "Natural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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