IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v415y2002i6875d10.1038_4151022a.html
   My bibliography  Save this article

Adaptive protein evolution in Drosophila

Author

Listed:
  • Nick G. C. Smith

    (Centre for the Study of Evolution and School of Biological Sciences, University of Sussex
    Uppsala University)

  • Adam Eyre-Walker

    (Centre for the Study of Evolution and School of Biological Sciences, University of Sussex)

Abstract

For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level1,2. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level3,4, but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species.

Suggested Citation

  • Nick G. C. Smith & Adam Eyre-Walker, 2002. "Adaptive protein evolution in Drosophila," Nature, Nature, vol. 415(6875), pages 1022-1024, February.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6875:d:10.1038_4151022a
    DOI: 10.1038/4151022a
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/4151022a
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/4151022a?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Benger, Etam & Sella, Guy, 2013. "Modeling the effect of changing selective pressures on polymorphism and divergence," Theoretical Population Biology, Elsevier, vol. 85(C), pages 73-85.
    2. Toni I Gossmann & David Waxman & Adam Eyre-Walker, 2014. "Fluctuating Selection Models and Mcdonald-Kreitman Type Analyses," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-5, January.
    3. Xinru Zhang & Bohao Fang & Yi-Fei Huang, 2023. "Transcription factor binding sites are frequently under accelerated evolution in primates," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Juan M Calvo-Martín & Montserrat Papaceit & Carmen Segarra, 2017. "Molecular population genetics of the Polycomb genes in Drosophila subobscura," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-15, September.
    5. Sella, Guy, 2009. "An exact steady state solution of Fisher’s geometric model and other models," Theoretical Population Biology, Elsevier, vol. 75(1), pages 30-34.
    6. Kirsten E Eilertson & James G Booth & Carlos D Bustamante, 2012. "SnIPRE: Selection Inference Using a Poisson Random Effects Model," PLOS Computational Biology, Public Library of Science, vol. 8(12), pages 1-14, December.
    7. Vogl, Claus & Mikula, Lynette Caitlin, 2021. "A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection," Theoretical Population Biology, Elsevier, vol. 139(C), pages 1-17.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:415:y:2002:i:6875:d:10.1038_4151022a. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.