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Insulin signalling and the regulation of glucose and lipid metabolism

Author

Listed:
  • Alan R. Saltiel

    (Life Sciences Institute, University of Michigan School of Medicine)

  • C. Ronald Kahn

    (Joslin Diabetes Centre, Harvard Medical School)

Abstract

The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes.

Suggested Citation

  • Alan R. Saltiel & C. Ronald Kahn, 2001. "Insulin signalling and the regulation of glucose and lipid metabolism," Nature, Nature, vol. 414(6865), pages 799-806, December.
    • Handle: RePEc:nat:nature:v:414:y:2001:i:6865:d:10.1038_414799a
    DOI: 10.1038/414799a
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    Cited by:

    1. Julian Krauskopf & Theo M de Kok & Shelli J Schomaker & Mark Gosink & Deborah A Burt & Patricia Chandler & Roscoe L Warner & Kent J Johnson & Florian Caiment & Jos C Kleinjans & Jiri Aubrecht, 2017. "Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-17, May.
    2. Yan-Ping Zhang & Wen-Hong Zhang & Pan Zhang & Qi Li & Yue Sun & Jia-Wen Wang & Shaobing O. Zhang & Tao Cai & Cheng Zhan & Meng-Qiu Dong, 2022. "Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Gunnar Cedersund & Jacob Roll & Erik Ulfhielm & Anna Danielsson & Henrik Tidefelt & Peter Strålfors, 2008. "Model-Based Hypothesis Testing of Key Mechanisms in Initial Phase of Insulin Signaling," PLOS Computational Biology, Public Library of Science, vol. 4(6), pages 1-10, June.
    4. Cemal Erdem & Sean M. Gross & Laura M. Heiser & Marc R. Birtwistle, 2023. "MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Nicholas S. Kirk & Qi Chen & Yingzhe Ginger Wu & Anastasia L. Asante & Haitao Hu & Juan F. Espinosa & Francisco Martínez-Olid & Mai B. Margetts & Faiz A. Mohammed & Vladislav V. Kiselyov & David G. Ba, 2022. "Activation of the human insulin receptor by non-insulin-related peptides," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. Sok Kuan Wong & Kok-Yong Chin & Farihah Hj Suhaimi & Fairus Ahmad & Soelaiman Ima-Nirwana, 2018. "The Effects of Vitamin E from Elaeis guineensis (Oil Palm) in a Rat Model of Bone Loss Due to Metabolic Syndrome," IJERPH, MDPI, vol. 15(9), pages 1-12, August.
    7. Lei Ying & Luyao Wang & Kaiwen Guo & Yushu Hou & Na Li & Shuyi Wang & Xingfeng Liu & Qijin Zhao & Jie Zhou & Longwei Zhao & Jianlou Niu & Chuchu Chen & Lintao Song & Shaocong Hou & Lijuan Kong & Xiaok, 2021. "Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    8. Katarina Baralić & Aleksandra Buha Djordjevic & Katarina Živančević & Evica Antonijević & Milena Anđelković & Dragana Javorac & Marijana Ćurčić & Zorica Bulat & Biljana Antonijević & Danijela Đukić-Ćo, 2020. "Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats," IJERPH, MDPI, vol. 17(3), pages 1-24, January.
    9. Yafei Yuan & Fang Kong & Hanwen Xu & Angqi Zhu & Nieng Yan & Chuangye Yan, 2022. "Cryo-EM structure of human glucose transporter GLUT4," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    10. Eunyoung Kim & Jiamei Cui & Inhae Kang & Guiguo Zhang & Yunkyoung Lee, 2021. "Potential Antidiabetic Effects of Seaweed Extracts by Upregulating Glucose Utilization and Alleviating Inflammation in C2C12 Myotubes," IJERPH, MDPI, vol. 18(3), pages 1-13, February.
    11. Mohd Zamri Bin Haji Ismail & Matt D Hodges & Michael Boylan & Rajesh Achall & Alan Shirras & Susan J Broughton, 2015. "The Drosophila Insulin Receptor Independently Modulates Lifespan and Locomotor Senescence," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-21, May.
    12. Fang Wang & Linfeng Lei & Zhaobin Wang & Yulong Yin & Huansheng Yang & Zhe Yang & Jiashun Chen, 2022. "Differentially expressed genes in the longissimus dorsi muscle between the Chinese indigenous Ningxiang pig and Large White breed using RNA sequencing," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 67(11), pages 442-453.
    13. Hui Xia & Charlotte Scholtes & Catherine R. Dufour & Carlo Ouellet & Majid Ghahremani & Vincent Giguère, 2022. "Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    14. Kaoru Ohashi & Hisako Komada & Shinsuke Uda & Hiroyuki Kubota & Toshinao Iwaki & Hiroki Fukuzawa & Yasunori Komori & Masashi Fujii & Yu Toyoshima & Kazuhiko Sakaguchi & Wataru Ogawa & Shinya Kuroda, 2015. "Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-19, December.

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