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Oxidants, oxidative stress and the biology of ageing

Author

Listed:
  • Toren Finkel

    (Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Building 10/6N-240)

  • Nikki J. Holbrook

    (Laboratory of Biological Chemistry, National Institute on Aging/National Institutes of Health)

Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

Suggested Citation

  • Toren Finkel & Nikki J. Holbrook, 2000. "Oxidants, oxidative stress and the biology of ageing," Nature, Nature, vol. 408(6809), pages 239-247, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6809:d:10.1038_35041687
    DOI: 10.1038/35041687
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    13. Marc Thilo Figge & Andreas S Reichert & Michael Meyer-Hermann & Heinz D Osiewacz, 2012. "Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging," PLOS Computational Biology, Public Library of Science, vol. 8(6), pages 1-18, June.
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    18. Panduranga Murthy G & Leelaja BC & Ravishankar HG & Dharshan Raj CG & Rajesh Kumar, 2018. "Evaluation of Neuroprotection and Antioxidant Activities via Drosophila Model System in the Active Principle Derived from Sida Glutinosa Comm. Ex Cav. - An Aboriginal Ethno-Medicinal Plant Drug Practi," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8855-8862, December.
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    20. Akiko Koto & Makoto Tamura & Pui Shan Wong & Sachiyo Aburatani & Eyal Privman & Céline Stoffel & Alessandro Crespi & Sean Keane McKenzie & Christine Mendola & Tomas Kay & Laurent Keller, 2023. "Social isolation shortens lifespan through oxidative stress in ants," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
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