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Oxidants, oxidative stress and the biology of ageing

Author

Listed:
  • Toren Finkel

    (Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Building 10/6N-240)

  • Nikki J. Holbrook

    (Laboratory of Biological Chemistry, National Institute on Aging/National Institutes of Health)

Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

Suggested Citation

  • Toren Finkel & Nikki J. Holbrook, 2000. "Oxidants, oxidative stress and the biology of ageing," Nature, Nature, vol. 408(6809), pages 239-247, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6809:d:10.1038_35041687
    DOI: 10.1038/35041687
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    Cited by:

    1. Marc Thilo Figge & Andreas S Reichert & Michael Meyer-Hermann & Heinz D Osiewacz, 2012. "Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging," PLOS Computational Biology, Public Library of Science, vol. 8(6), pages 1-18, June.
    2. Xinyue Zhang & Xiaolu Gao & Danxian Wu & Zening Xu & Hongjie Wang, 2021. "The Role of Big Data in Aging and Older People’s Health Research: A Systematic Review and Ecological Framework," Sustainability, MDPI, vol. 13(21), pages 1-19, October.
    3. Mustafa Mortas, 2023. "Characterization of a New Powdered, Milk-Based Medicinal Plant ( Alcea rosea ) Drink Product," Sustainability, MDPI, vol. 15(12), pages 1-14, June.
    4. Hill, Terrence D. & Ellison, Christopher G. & Burdette, Amy M. & Taylor, John & Friedman, Katherine L., 2016. "Dimensions of religious involvement and leukocyte telomere length," Social Science & Medicine, Elsevier, vol. 163(C), pages 168-175.
    5. Cheol Park & Da Hye Kwon & Su Jung Hwang & Min Ho Han & Jin-Woo Jeong & Sang Hoon Hong & Hee-Jae Cha & Su-Hyun Hong & Gi-Young Kim & Hyo-Jong Lee & Suhkmann Kim & Heui-Soo Kim & Yung Hyun Choi, 2019. "Protective Effects of Nargenicin A1 against Tacrolimus-Induced Oxidative Stress in Hirame Natural Embryo Cells," IJERPH, MDPI, vol. 16(6), pages 1-13, March.
    6. Hyo Sub Choi & Ajay Bhat & Marshall B. Howington & Megan L. Schaller & Rebecca L. Cox & Shijiao Huang & Safa Beydoun & Hillary A. Miller & Angela M. Tuckowski & Joy Mecano & Elizabeth S. Dean & Lindy , 2023. "FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Cheol Park & Su Hyun Hong & Soon Shik Shin & Dae-Sung Lee & Min Ho Han & Hee-Jae Cha & Suhkmann Kim & Heui-Soo Kim & Gi-Young Kim & Eui Kyun Park & You-Jin Jeon & Yung Hyun Choi, 2018. "Activation of the Nrf2/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract against Oxidative Stress-Induced DNA Damage and Apoptosis in SW1353 Human Chondro," IJERPH, MDPI, vol. 15(6), pages 1-13, June.
    8. Jamie L. Endicott & Paula A. Nolte & Hui Shen & Peter W. Laird, 2022. "Cell division drives DNA methylation loss in late-replicating domains in primary human cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Benu George & Pradeep Varathan & T. V. Suchithra, 2020. "Meta-analysis on big data of bioactive compounds from mangrove ecosystem to treat neurodegenerative disease," Scientometrics, Springer;Akadémiai Kiadó, vol. 122(3), pages 1539-1561, March.
    10. Anna Mikołajczak & Marta Ligaj & Joanna Kobus-Cisowska, 2022. "Temperature Optimization by Electrochemical Method for Improving Antioxidant Compound Extraction Efficiency from Origanum vulgare L. and Its Application in a Bread Production," Sustainability, MDPI, vol. 14(5), pages 1-11, February.
    11. Dan Zhang & Yongjie Sun & Zhichao Wang & Fang Liu & Xuanjun Zhang, 2023. "Switchable biomimetic nanochannels for on-demand SO2 detection by light-controlled photochromism," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    12. Mohamed Saber Numan & Jacques P. Brown & Laëtitia Michou, 2015. "Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases," IJERPH, MDPI, vol. 12(2), pages 1-17, February.
    13. Onni Niemelä, 2016. "Biomarker-Based Approaches for Assessing Alcohol Use Disorders," IJERPH, MDPI, vol. 13(2), pages 1-19, January.
    14. K. A. Gajewska & H. Lescesen & M. Ramialison & K. M. Wagstaff & D. A. Jans, 2021. "Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    15. Panduranga Murthy G & Leelaja BC & Ravishankar HG & Dharshan Raj CG & Rajesh Kumar, 2018. "Evaluation of Neuroprotection and Antioxidant Activities via Drosophila Model System in the Active Principle Derived from Sida Glutinosa Comm. Ex Cav. - An Aboriginal Ethno-Medicinal Plant Drug Practi," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8855-8862, December.
    16. Xin Liu & Danhao Wang & Wei Chen & Yang Kang & Shi Fang & Yuanmin Luo & Dongyang Luo & Huabin Yu & Haochen Zhang & Kun Liang & Lan Fu & Boon S. Ooi & Sheng Liu & Haiding Sun, 2024. "Optoelectronic synapses with chemical-electric behaviors in gallium nitride semiconductors for biorealistic neuromorphic functionality," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    17. Mirre J P Simons & Alan A Cohen & Simon Verhulst, 2012. "What Does Carotenoid-Dependent Coloration Tell? Plasma Carotenoid Level Signals Immunocompetence and Oxidative Stress State in Birds–A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-1, August.
    18. Akiko Koto & Makoto Tamura & Pui Shan Wong & Sachiyo Aburatani & Eyal Privman & Céline Stoffel & Alessandro Crespi & Sean Keane McKenzie & Christine Mendola & Tomas Kay & Laurent Keller, 2023. "Social isolation shortens lifespan through oxidative stress in ants," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    19. Victória Assis & Ivo Vieira de Sousa Neto & Filipe M. Ribeiro & Rita de Cassia Marqueti & Octávio Luiz Franco & Samuel da Silva Aguiar & Bernardo Petriz, 2022. "The Emerging Role of the Aging Process and Exercise Training on the Crosstalk between Gut Microbiota and Telomere Length," IJERPH, MDPI, vol. 19(13), pages 1-11, June.
    20. Daniel L Belavý & Ulf Gast & Martin Daumer & Elena Fomina & Rainer Rawer & Hans Schießl & Stefan Schneider & Harald Schubert & Cristina Soaz & Dieter Felsenberg, 2013. "Progressive Adaptation in Physical Activity and Neuromuscular Performance during 520d Confinement," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-7, March.
    21. Natasha B. Scott & Nicola S. Pocock, 2021. "The Health Impacts of Hazardous Chemical Exposures among Child Labourers in Low- and Middle-Income Countries," IJERPH, MDPI, vol. 18(10), pages 1-34, May.
    22. Leandro V.B. Carvalho & Sandra S. Hacon & Claudia M. Vega & Jucilene A. Vieira & Ariane L. Larentis & Rita C. O. C. Mattos & Daniel Valente & Isabele C. Costa-Amaral & Dennys S. Mourão & Gabriela P. S, 2019. "Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil," IJERPH, MDPI, vol. 16(15), pages 1-15, July.

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