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Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil

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  • Leandro V.B. Carvalho

    (Toxicology Laboratory, Center for Studies of Worker’s Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Sandra S. Hacon

    (Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Claudia M. Vega

    (Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil
    Centro de Innovaccion Cientifica Amazonica (CINCIA), Jr. Cajamarca c 1 s/n, Puerto Candamo, Puerto Maldonado, Madre de Dios, PERU - Wake Forest University, 1834 Wake Forest Rd, Winston-Salem, NC 27109, USA)

  • Jucilene A. Vieira

    (Toxicology Laboratory, Center for Studies of Worker’s Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Ariane L. Larentis

    (Toxicology Laboratory, Center for Studies of Worker’s Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Rita C. O. C. Mattos

    (Toxicology Laboratory, Center for Studies of Worker’s Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Daniel Valente

    (Toxicology Laboratory, Center for Studies of Worker’s Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Isabele C. Costa-Amaral

    (Toxicology Laboratory, Center for Studies of Worker’s Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Dennys S. Mourão

    (Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Gabriela P. Silva

    (Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

  • Beatriz F. A. Oliveira

    (Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil)

Abstract

Oxidative stress can be induced by mercury (Hg) exposure, including through fish consumption (diet), leading to health risks. The objective of this study was to evaluate the association between oxidative stress biomarkers and dietary Hg exposure levels in riverine children and adolescents at Madeira River (RO/Brazil). Population from three riverine local communities presenting different fish consumption frequencies was sampled. Hg was determined in blood (ICP-MS) and glutathione (GSH); glutathione S-transferases (GST) and malondialdehyde (MDA) were determined in serum (spectrophotometry). Statistical analyses were performed using parametric and non-parametric tests. Multiple linear regression models and generalized additives models were also used to estimate the relationships between oxidative stress biomarkers and blood Hg. The juvenile riverine population from Cuniã RESEX presented the highest levels of oxidative stress and Hg levels in blood (GST = 27.2 (4.93) U/L, MDA = 1.69 (0.27) µmol/L, Hg = 20.6 (18.0) µg/L). This population also presented the highest frequency of fish consumption. The positive relation between Hg and GST and MDA, adjusted for individual characteristics, suggests an oxidative effect. This study shows the importance of oxidative stress biomarkers in the evaluation of dietary Hg exposure since initial and reversible metabolic changes were observed, enriching health risk assessments.

Suggested Citation

  • Leandro V.B. Carvalho & Sandra S. Hacon & Claudia M. Vega & Jucilene A. Vieira & Ariane L. Larentis & Rita C. O. C. Mattos & Daniel Valente & Isabele C. Costa-Amaral & Dennys S. Mourão & Gabriela P. S, 2019. "Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil," IJERPH, MDPI, vol. 16(15), pages 1-15, July.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:15:p:2682-:d:252199
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    References listed on IDEAS

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    1. Toren Finkel & Nikki J. Holbrook, 2000. "Oxidants, oxidative stress and the biology of ageing," Nature, Nature, vol. 408(6809), pages 239-247, November.
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    1. Mohammad H. Rahbar & Maureen Samms-Vaughan & Sepideh Saroukhani & Jan Bressler & Manouchehr Hessabi & Megan L. Grove & Sydonnie Shakspeare-Pellington & Katherine A. Loveland & Compton Beecher & Wayne , 2021. "Associations of Metabolic Genes ( GSTT1 , GSTP1 , GSTM1 ) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 18(4), pages 1-20, February.

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