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Angiogenesis in cancer and other diseases

Author

Listed:
  • Peter Carmeliet

    (The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology)

  • Rakesh K. Jain

    (Massachusetts General Hospital and Harvard Medical School)

Abstract

Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of pro- and anti-angiogenic molecules, some of which are already in clinical trials. The complex interactions among these molecules and how they affect vascular structure and function in different environments are now beginning to be elucidated. This integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases. But owing to several unanswered questions, caution is needed.

Suggested Citation

  • Peter Carmeliet & Rakesh K. Jain, 2000. "Angiogenesis in cancer and other diseases," Nature, Nature, vol. 407(6801), pages 249-257, September.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6801:d:10.1038_35025220
    DOI: 10.1038/35025220
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    Cited by:

    1. Rocío Vega & Manuel Carretero & Rui D M Travasso & Luis L Bonilla, 2020. "Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model," PLOS Computational Biology, Public Library of Science, vol. 16(1), pages 1-31, January.
    2. Klaus Eickel & David Andrew Porter & Anika Söhner & Marc Maaß & Lutz Lüdemann & Matthias Günther, 2018. "Simultaneous multislice acquisition with multi-contrast segmented EPI for separation of signal contributions in dynamic contrast-enhanced imaging," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-22, August.
    3. Bin Wu & Haixiang Wu & Xiaoyan Liu & Houwen Lin & Jin Li, 2014. "Ranibizumab versus Bevacizumab for Ophthalmic Diseases Related to Neovascularisation: A Meta-Analysis of Randomised Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-8, July.
    4. Harman Ghuman & Kyungsoo Kim & Sapeeda Barati & Karunesh Ganguly, 2023. "Emergence of task-related spatiotemporal population dynamics in transplanted neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Wenhua Liang & Xuan Wu & Shaodong Hong & Yaxiong Zhang & Shiyang Kang & Wenfeng Fang & Tao Qin & Yan Huang & Hongyun Zhao & Li Zhang, 2014. "Multi-Targeted Antiangiogenic Tyrosine Kinase Inhibitors in Advanced Non-Small Cell Lung Cancer: Meta-Analyses of 20 Randomized Controlled Trials and Subgroup Analyses," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-7, October.
    6. Sara G. Romeo & Ilaria Secco & Edoardo Schneider & Christina M. Reumiller & Celio X. C. Santos & Anna Zoccarato & Vishal Musale & Aman Pooni & Xiaoke Yin & Konstantinos Theofilatos & Silvia Cellone Tr, 2023. "Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Ze-Feng Zhang & Tao Wang & Li-Hua Liu & Hui-Qin Guo, 2014. "Risks of Proteinuria Associated with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    8. Sadhukhan, Sounak & Mishra, P.K., 2022. "The notion of fractals in tumour angiogenic sprout initiation model based on cellular automata," Chaos, Solitons & Fractals, Elsevier, vol. 155(C).
    9. Sun Young Lee & Farhan Haq & Deokhoon Kim & Cui Jun & Hui-Jong Jo & Sung-Min Ahn & Won-Suk Lee, 2014. "Comparative Genomic Analysis of Primary and Synchronous Metastatic Colorectal Cancers," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-9, March.
    10. Kimio Takeuchi & Ryoji Yanai & Fumiaki Kumase & Yuki Morizane & Jun Suzuki & Maki Kayama & Katarzyna Brodowska & Mitsuru Nakazawa & Joan W Miller & Kip M Connor & Demetrios G Vavvas, 2014. "EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    11. Hailong He & Christine Schönmann & Mathias Schwarz & Benedikt Hindelang & Andrei Berezhnoi & Susanne Annette Steimle-Grauer & Ulf Darsow & Juan Aguirre & Vasilis Ntziachristos, 2022. "Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    12. Yi Sun & Yao Wang & Shu Yuan & Jialing Wen & Weiyu Li & Liu Yang & Xiaoyan Huang & Yanmei Mo & Yingqi Zhao & Yuanming Lu, 2018. "Exposure to PM2.5 via vascular endothelial growth factor relationship: Meta-analysis," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-12, June.

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