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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

Author

Listed:
  • C. K. Stover

    (PathoGenesis Corporation)

  • X. Q. Pham

    (Box 352145, University of Washington)

  • A. L. Erwin

    (PathoGenesis Corporation)

  • S. D. Mizoguchi

    (PathoGenesis Corporation)

  • P. Warrener

    (PathoGenesis Corporation)

  • M. J. Hickey

    (PathoGenesis Corporation)

  • F.S. L. Brinkman

    (Department of Microbiology and Immunology University of British Columbia)

  • W. O. Hufnagle

    (PathoGenesis Corporation)

  • D. J. Kowalik

    (PathoGenesis Corporation)

  • M. Lagrou

    (PathoGenesis Corporation)

  • R. L. Garber

    (PathoGenesis Corporation)

  • L. Goltry

    (PathoGenesis Corporation)

  • E. Tolentino

    (PathoGenesis Corporation)

  • S. Westbrock-Wadman

    (PathoGenesis Corporation)

  • Y. Yuan

    (PathoGenesis Corporation)

  • L. L. Brody

    (PathoGenesis Corporation)

  • S. N. Coulter

    (PathoGenesis Corporation)

  • K. R. Folger

    (PathoGenesis Corporation)

  • A. Kas

    (Box 352145, University of Washington)

  • K. Larbig

    (Klinische Forschergruppe, Medizinische Hochschule Hannover)

  • R. Lim

    (Box 352145, University of Washington)

  • K. Smith

    (Box 352145, University of Washington)

  • D. Spencer

    (Box 352145, University of Washington)

  • G. K.-S. Wong

    (Box 352145, University of Washington)

  • Z. Wu

    (Box 352145, University of Washington)

  • I. T. Paulsen

    (The Institute for Genomic Research, 9712 Medical Center
    University of California at San Diego)

  • J. Reizer

    (University of California at San Diego)

  • M. H. Saier

    (University of California at San Diego)

  • R. E. W. Hancock

    (Department of Microbiology and Immunology University of British Columbia)

  • S. Lory

    (University of Washington School of Medicine)

  • M. V. Olson

    (Box 352145, University of Washington)

Abstract

Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

Suggested Citation

  • C. K. Stover & X. Q. Pham & A. L. Erwin & S. D. Mizoguchi & P. Warrener & M. J. Hickey & F.S. L. Brinkman & W. O. Hufnagle & D. J. Kowalik & M. Lagrou & R. L. Garber & L. Goltry & E. Tolentino & S. We, 2000. "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen," Nature, Nature, vol. 406(6799), pages 959-964, August.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6799:d:10.1038_35023079
    DOI: 10.1038/35023079
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    Cited by:

    1. Shanshan Li & Keke Qian & Shan Wang & Kaiqiang Liang & Wei Yan, 2017. "Polypyrrole-Grafted Coconut Shell Biological Carbon as a Potential Adsorbent for Methyl Tert -Butyl Ether Removal: Characterization and Adsorption Capability," IJERPH, MDPI, vol. 14(2), pages 1-15, January.
    2. Andreea A. Gheorghita & Yancheng E. Li & Elena N. Kitova & Duong T. Bui & Roland Pfoh & Kristin E. Low & Gregory B. Whitfield & Marthe T. C. Walvoort & Qingju Zhang & Jeroen D. C. Codée & John S. Klas, 2022. "Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Dan Xiao & Wen Zhang & Xiaoting Guo & Yidong Liu & Chunxia Hu & Shiting Guo & Zhaoqi Kang & Xianzhi Xu & Cuiqing Ma & Chao Gao & Ping Xu, 2021. "A d-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Lise Goltermann & Pablo Laborda & Oihane Irazoqui & Ivan Pogrebnyakov & Maria Pals Bendixen & Søren Molin & Helle Krogh Johansen & Ruggero La Rosa, 2024. "Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Julian Trouillon & Kook Han & Ina Attrée & Stephen Lory, 2022. "The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Hanne Hendrix & Annabel Itterbeek & Hannelore Longin & Lize Delanghe & Eveline Vriens & Marta Vallino & Eveline-Marie Lammens & Farhana Haque & Ahmed Yusuf & Jean-Paul Noben & Maarten Boon & Matthias , 2024. "PlzR regulates type IV pili assembly in Pseudomonas aeruginosa via PilZ binding," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    7. Kimberley R. Miner & Paul Andrew Mayewski & Mary Hubbard & Kenny Broad & Heather Clifford & Imogen Napper & Ananta Gajurel & Corey Jaskolski & Wei Li & Mariusz Potocki & John Priscu, 2021. "A Perspective of the Cumulative Risks from Climate Change on Mt. Everest: Findings from the 2019 Expedition," IJERPH, MDPI, vol. 18(4), pages 1-13, February.
    8. Fenglin Li & Chun-Feng David Hou & Ravi K. Lokareddy & Ruoyu Yang & Francesca Forti & Federica Briani & Gino Cingolani, 2023. "High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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