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Immediate neurophysiological effects of transcranial electrical stimulation

Author

Listed:
  • Anli Liu

    (New York University Comprehensive Epilepsy Center
    NYU Langone Health)

  • Mihály Vöröslakos

    (University of Szeged
    New York University Neuroscience Institute)

  • Greg Kronberg

    (City College of New York)

  • Simon Henin

    (New York University Comprehensive Epilepsy Center
    NYU Langone Health)

  • Matthew R. Krause

    (McGill University)

  • Yu Huang

    (City College of New York)

  • Alexander Opitz

    (Department of Biomedical Engineering of Minnesota)

  • Ashesh Mehta

    (Hofstra Northwell School of Medicine
    Hofstra Northwell School of Medicine)

  • Christopher C. Pack

    (McGill University)

  • Bart Krekelberg

    (Rutgers University)

  • Antal Berényi

    (University of Szeged)

  • Lucas C. Parra

    (City College of New York)

  • Lucia Melloni

    (New York University Comprehensive Epilepsy Center
    NYU Langone Health
    Max Planck Institute for Empirical Aesthetics)

  • Orrin Devinsky

    (New York University Comprehensive Epilepsy Center
    NYU Langone Health)

  • György Buzsáki

    (New York University Neuroscience Institute)

Abstract

Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its convenience and potential as a chronic therapy. However, a mechanistic understanding of TES has lagged behind its widespread adoption. Here, we review data and modelling on the immediate neurophysiological effects of TES in vitro as well as in vivo in both humans and other animals. While it remains unclear how typical TES protocols affect neural activity, we propose that validated models of current flow should inform study design and artifacts should be carefully excluded during signal recording and analysis. Potential indirect effects of TES (e.g., peripheral stimulation) should be investigated in more detail and further explored in experimental designs. We also consider how novel technologies may stimulate the next generation of TES experiments and devices, thus enhancing validity, specificity, and reproducibility.

Suggested Citation

  • Anli Liu & Mihály Vöröslakos & Greg Kronberg & Simon Henin & Matthew R. Krause & Yu Huang & Alexander Opitz & Ashesh Mehta & Christopher C. Pack & Bart Krekelberg & Antal Berényi & Lucas C. Parra & Lu, 2018. "Immediate neurophysiological effects of transcranial electrical stimulation," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07233-7
    DOI: 10.1038/s41467-018-07233-7
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    Cited by:

    1. Harman Ghuman & Kyungsoo Kim & Sapeeda Barati & Karunesh Ganguly, 2023. "Emergence of task-related spatiotemporal population dynamics in transplanted neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Miles Wischnewski & Harry Tran & Zhihe Zhao & Sina Shirinpour & Zachary J. Haigh & Jonna Rotteveel & Nipun D. Perera & Ivan Alekseichuk & Jan Zimmermann & Alexander Opitz, 2024. "Induced neural phase precession through exogenous electric fields," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Daria Antonenko & Anna Elisabeth Fromm & Friederike Thams & Ulrike Grittner & Marcus Meinzer & Agnes Flöel, 2023. "Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Giulio Ruffini & Ricardo Salvador & Ehsan Tadayon & Roser Sanchez-Todo & Alvaro Pascual-Leone & Emiliano Santarnecchi, 2020. "Realistic modeling of mesoscopic ephaptic coupling in the human brain," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-25, June.
    5. Lu, Qingchang & Farooq, Muhammad Umar & Ma, Xiaoyu & Iram, Robina, 2022. "Assessing the combining role of public-private investment as a green finance and renewable energy in carbon neutrality target," Renewable Energy, Elsevier, vol. 196(C), pages 1357-1365.
    6. Pedro G. Vieira & Matthew R. Krause & Christopher C. Pack, 2024. "Temporal interference stimulation disrupts spike timing in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Leon C Reteig & Lionel A Newman & K Richard Ridderinkhof & Heleen A Slagter, 2022. "Effects of tDCS on the attentional blink revisited: A statistical evaluation of a replication attempt," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-23, January.

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