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Robust hemostatic bandages based on nanoclay electrospun membranes

Author

Listed:
  • Yan Cui

    (Central South University
    Central South University)

  • Zongwang Huang

    (Central South University)

  • Li Lei

    (the Third Xiangya Hospital, Central South University)

  • Qinglin Li

    (Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
    Chinese Academy of Sciences)

  • Jinlong Jiang

    (Huaiyin Institute of Technology)

  • Qinghai Zeng

    (the Third Xiangya Hospital, Central South University)

  • Aidong Tang

    (Central South University)

  • Huaming Yang

    (Central South University)

  • Yi Zhang

    (Central South University)

Abstract

Death from acute hemorrhage is a major problem in military conflicts, traffic accidents, and surgical procedures, et al. Achieving rapid effective hemostasis for pre-hospital care is essential to save lives in massive bleeding. An ideal hemostasis material should have those features such as safe, efficient, convenient, economical, which remains challenging and most of them cannot be achieved at the same time. In this work, we report a rapid effective nanoclay-based hemostatic membranes with nanoclay particles incorporate into polyvinylpyrrolidone (PVP) electrospun fibers. The nanoclay electrospun membrane (NEM) with 60 wt% kaolinite (KEM1.5) shows better and faster hemostatic performance in vitro and in vivo with good biocompatibility compared with most other NEMs and clay-based hemostats, benefiting from its enriched hemostatic functional sites, robust fluffy framework, and hydrophilic surface. The robust hemostatic bandages based on nanoclay electrospun membrane is an effective candidate hemostat in practical application.

Suggested Citation

  • Yan Cui & Zongwang Huang & Li Lei & Qinglin Li & Jinlong Jiang & Qinghai Zeng & Aidong Tang & Huaming Yang & Yi Zhang, 2021. "Robust hemostatic bandages based on nanoclay electrospun membranes," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26237-4
    DOI: 10.1038/s41467-021-26237-4
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    References listed on IDEAS

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    1. Xin Zhao & Baolin Guo & Hao Wu & Yongping Liang & Peter X. Ma, 2018. "Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
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