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The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat

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  • Wen Yang

    (China Agricultural University)

  • Man Feng

    (China Agricultural University)

  • Kuohai Yu

    (China Agricultural University)

  • Jie Cao

    (China Agricultural University)

  • Guangxian Cui

    (China Agricultural University)

  • Yumei Zhang

    (Qingdao Agricultural University)

  • Huiru Peng

    (China Agricultural University)

  • Yingyin Yao

    (China Agricultural University)

  • Zhaorong Hu

    (China Agricultural University)

  • Zhongfu Ni

    (China Agricultural University)

  • Feng Qin

    (China Agricultural University)

  • Fuminori Takahashi

    (Tokyo University of Science)

  • Qixin Sun

    (China Agricultural University)

  • Mingming Xin

    (China Agricultural University)

Abstract

Plant peptide hormones play an important role in regulating root development and stress responses. Here, we identify a root-derived CLAVATA3/Endosperm surrounding region-related (CLE) peptide TaCLE24b and its leucine-rich repeat receptor-like kinase CLAVATA1 (CLV1) TaCLV1, which together regulate the formation of lateral root primordium and the outgrowth of lateral root in wheat. Additionally, a loss-of-function mutation of TaSG-D1, encoding a Ser/Thr protein kinase glycogen synthase kinase 3 (STKc_GSK3), also enhances the formation of lateral root primordium and the outgrowth of lateral roots in wheat. Furthermore, TaCLV1 interacts with TaSG-D1, leading to phosphorylation and degradation of TaSG-D1. Whereas the presence of TaCLE24b enhances the binding affinity and phosphorylation ability of TaCLV1 to TaSG-D1, thereby positively fine-tuning lateral root development and contributing to drought tolerance in wheat. Overall, our findings provide new insights into the significance of the peptide signaling pathway in regulating lateral root development and responding to drought stress in wheat.

Suggested Citation

  • Wen Yang & Man Feng & Kuohai Yu & Jie Cao & Guangxian Cui & Yumei Zhang & Huiru Peng & Yingyin Yao & Zhaorong Hu & Zhongfu Ni & Feng Qin & Fuminori Takahashi & Qixin Sun & Mingming Xin, 2025. "The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57291-x
    DOI: 10.1038/s41467-025-57291-x
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    1. Josh Abramson & Jonas Adler & Jack Dunger & Richard Evans & Tim Green & Alexander Pritzel & Olaf Ronneberger & Lindsay Willmore & Andrew J. Ballard & Joshua Bambrick & Sebastian W. Bodenstein & David , 2024. "Accurate structure prediction of biomolecular interactions with AlphaFold 3," Nature, Nature, vol. 630(8016), pages 493-500, June.
    2. Mark T. Osterlund & Christian S. Hardtke & Ning Wei & Xing Wang Deng, 2000. "Targeted destabilization of HY5 during light-regulated development of Arabidopsis," Nature, Nature, vol. 405(6785), pages 462-466, May.
    3. Josh Abramson & Jonas Adler & Jack Dunger & Richard Evans & Tim Green & Alexander Pritzel & Olaf Ronneberger & Lindsay Willmore & Andrew J. Ballard & Joshua Bambrick & Sebastian W. Bodenstein & David , 2024. "Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3," Nature, Nature, vol. 636(8042), pages 4-4, December.
    4. Fuminori Takahashi & Takehiro Suzuki & Yuriko Osakabe & Shigeyuki Betsuyaku & Yuki Kondo & Naoshi Dohmae & Hiroo Fukuda & Kazuko Yamaguchi-Shinozaki & Kazuo Shinozaki, 2018. "A small peptide modulates stomatal control via abscisic acid in long-distance signalling," Nature, Nature, vol. 556(7700), pages 235-238, April.
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