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Targeted destabilization of HY5 during light-regulated development of Arabidopsis

Author

Listed:
  • Mark T. Osterlund

    (Cellular and Developmental Biology, Yale University, PO Box 208104)

  • Christian S. Hardtke

    (Cellular and Developmental Biology, Yale University, PO Box 208104)

  • Ning Wei

    (Cellular and Developmental Biology, Yale University, PO Box 208104)

  • Xing Wang Deng

    (Cellular and Developmental Biology, Yale University, PO Box 208104)

Abstract

Arabidopsis seedlings display contrasting developmental patterns depending on the ambient light. Seedlings grown in the light develop photomorphogenically, characterized by short hypocotyls and expanded green cotyledons. In contrast, seedlings grown in darkness become etiolated, with elongated hypocotyls and closed cotyledons on an apical hook. Light signals, perceived by multiple photoreceptors and transduced to downstream regulators, dictate the extent of photomorphogenic development in a quantitative manner. Two key downstream components, COP1 and HY5, act antagonistically in regulating seedling development1. HY5 is a bZIP transcription factor that binds directly to the promoters of light-inducible genes, promoting their expression and photomorphogenic development2,3. COP1 is a RING-finger protein with WD-40 repeats whose nuclear abundance is negatively regulated by light4,5. COP1 interacts directly with HY5 in the nucleus to regulate its activity negatively1. Here we show that the abundance of HY5 is directly correlated with the extent of photomorphogenic development, and that the COP1–HY5 interaction may specifically target HY5 for proteasome-mediated degradation in the nucleus.

Suggested Citation

  • Mark T. Osterlund & Christian S. Hardtke & Ning Wei & Xing Wang Deng, 2000. "Targeted destabilization of HY5 during light-regulated development of Arabidopsis," Nature, Nature, vol. 405(6785), pages 462-466, May.
    • Handle: RePEc:nat:nature:v:405:y:2000:i:6785:d:10.1038_35013076
    DOI: 10.1038/35013076
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    Cited by:

    1. Mariola Staniak & Ewa Szpunar-Krok & Anna Kocira, 2023. "Responses of Soybean to Selected Abiotic Stresses—Photoperiod, Temperature and Water," Agriculture, MDPI, vol. 13(1), pages 1-28, January.
    2. Shichen Li & Zhihui Sun & Qing Sang & Chao Qin & Lingping Kong & Xin Huang & Huan Liu & Tong Su & Haiyang Li & Milan He & Chao Fang & Lingshuang Wang & Shuangrong Liu & Bin Liu & Baohui Liu & Xiangdon, 2023. "Soybean reduced internode 1 determines internode length and improves grain yield at dense planting," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Dunpin Xiong & Juan Wang & Ruci Wang & Yueming Wang & Yi Li & Ge Sun & Shanguo Yao, 2024. "A point mutation in VIG1 boosts development and chilling tolerance in rice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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