Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization
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DOI: 10.1038/s41467-025-56501-w
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- Wei Zuo & Ting Zhang & Daniel Zheng'An Wu & Shou Ping Guan & Audrey-Ann Liew & Yusuke Yamamoto & Xia Wang & Siew Joo Lim & Matthew Vincent & Mark Lessard & Christopher P. Crum & Wa Xian & Frank McKeon, 2015. "p63+Krt5+ distal airway stem cells are essential for lung regeneration," Nature, Nature, vol. 517(7536), pages 616-620, January.
- Kyle J. Travaglini & Ahmad N. Nabhan & Lolita Penland & Rahul Sinha & Astrid Gillich & Rene V. Sit & Stephen Chang & Stephanie D. Conley & Yasuo Mori & Jun Seita & Gerald J. Berry & Joseph B. Shrager , 2020. "A molecular cell atlas of the human lung from single-cell RNA sequencing," Nature, Nature, vol. 587(7835), pages 619-625, November.
- Benedikt Jaeger & Jonas Christian Schupp & Linda Plappert & Oliver Terwolbeck & Nataliia Artysh & Gian Kayser & Peggy Engelhard & Taylor Sterling Adams & Robert Zweigerdt & Henning Kempf & Stefan Lien, 2022. "Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Xia Wang & Yusuke Yamamoto & Lane H. Wilson & Ting Zhang & Brooke E. Howitt & Melissa A. Farrow & Florian Kern & Gang Ning & Yue Hong & Chiea Chuen Khor & Benoit Chevalier & Denis Bertrand & Lingyan W, 2015. "Cloning and variation of ground state intestinal stem cells," Nature, Nature, vol. 522(7555), pages 173-178, June.
- William J. Zacharias & David B. Frank & Jarod A. Zepp & Michael P. Morley & Farrah A. Alkhaleel & Jun Kong & Su Zhou & Edward Cantu & Edward E. Morrisey, 2018. "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor," Nature, Nature, vol. 555(7695), pages 251-255, March.
- Andrew E. Vaughan & Alexis N. Brumwell & Ying Xi & Jeffrey E. Gotts & Doug G. Brownfield & Barbara Treutlein & Kevin Tan & Victor Tan & Feng Chun Liu & Mark R. Looney & Michael A. Matthay & Jason R. R, 2015. "Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury," Nature, Nature, vol. 517(7536), pages 621-625, January.
- Barbara Treutlein & Doug G. Brownfield & Angela R. Wu & Norma F. Neff & Gary L. Mantalas & F. Hernan Espinoza & Tushar J. Desai & Mark A. Krasnow & Stephen R. Quake, 2014. "Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq," Nature, Nature, vol. 509(7500), pages 371-375, May.
- Astrid Gillich & Fan Zhang & Colleen G. Farmer & Kyle J. Travaglini & Serena Y. Tan & Mingxia Gu & Bin Zhou & Jeffrey A. Feinstein & Mark A. Krasnow & Ross J. Metzger, 2020. "Capillary cell-type specialization in the alveolus," Nature, Nature, vol. 586(7831), pages 785-789, October.
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