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p63+Krt5+ distal airway stem cells are essential for lung regeneration

Author

Listed:
  • Wei Zuo

    (Genome Institute of Singapore, A-STAR, 138672 Singapore)

  • Ting Zhang

    (Genome Institute of Singapore, A-STAR, 138672 Singapore)

  • Daniel Zheng'An Wu

    (Genome Institute of Singapore, A-STAR, 138672 Singapore)

  • Shou Ping Guan

    (Genome Institute of Singapore, A-STAR, 138672 Singapore)

  • Audrey-Ann Liew

    (Genome Institute of Singapore, A-STAR, 138672 Singapore)

  • Yusuke Yamamoto

    (The Jackson Laboratory for Genomic Medicine)

  • Xia Wang

    (The Jackson Laboratory for Genomic Medicine)

  • Siew Joo Lim

    (Genome Institute of Singapore, A-STAR, 138672 Singapore)

  • Matthew Vincent

    (Advanced Cell Technologies)

  • Mark Lessard

    (The Jackson Laboratory)

  • Christopher P. Crum

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Wa Xian

    (Genome Institute of Singapore, A-STAR, 138672 Singapore
    The Jackson Laboratory for Genomic Medicine
    Brigham and Women’s Hospital, Harvard Medical School
    National University Health System, 119228 Singapore)

  • Frank McKeon

    (Genome Institute of Singapore, A-STAR, 138672 Singapore
    The Jackson Laboratory for Genomic Medicine
    National University Health System, 119228 Singapore)

Abstract

Many patients experiencing sudden loss of lung tissue somehow undergo full recovery; here this recovery is traced to a discrete population of lung stem cells that are not only essential for lung regeneration but can be cloned and then transplanted to other mice to contribute new lung tissue.

Suggested Citation

  • Wei Zuo & Ting Zhang & Daniel Zheng'An Wu & Shou Ping Guan & Audrey-Ann Liew & Yusuke Yamamoto & Xia Wang & Siew Joo Lim & Matthew Vincent & Mark Lessard & Christopher P. Crum & Wa Xian & Frank McKeon, 2015. "p63+Krt5+ distal airway stem cells are essential for lung regeneration," Nature, Nature, vol. 517(7536), pages 616-620, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7536:d:10.1038_nature13903
    DOI: 10.1038/nature13903
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    Cited by:

    1. Laura Heydemann & Małgorzata Ciurkiewicz & Georg Beythien & Kathrin Becker & Klaus Schughart & Stephanie Stanelle-Bertram & Berfin Schaumburg & Nancy Mounogou-Kouassi & Sebastian Beck & Martin Zickler, 2023. "Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Andrew K. Beppu & Juanjuan Zhao & Changfu Yao & Gianni Carraro & Edo Israely & Anna Lucia Coelho & Katherine Drake & Cory M. Hogaboam & William C. Parks & Jay K. Kolls & Barry R. Stripp, 2023. "Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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