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Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

Author

Listed:
  • William J. Zacharias

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania)

  • David B. Frank

    (Penn Center for Pulmonary Biology, University of Pennsylvania
    Children’s Hospital of Philadelphia
    Penn Cardiovascular Institute, University of Pennsylvania)

  • Jarod A. Zepp

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania)

  • Michael P. Morley

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania
    Penn Cardiovascular Institute, University of Pennsylvania)

  • Farrah A. Alkhaleel

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania)

  • Jun Kong

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania)

  • Su Zhou

    (University of Pennsylvania
    Penn Cardiovascular Institute, University of Pennsylvania)

  • Edward Cantu

    (University of Pennsylvania)

  • Edward E. Morrisey

    (University of Pennsylvania
    Penn Center for Pulmonary Biology, University of Pennsylvania
    Penn Cardiovascular Institute, University of Pennsylvania
    University of Pennsylvania, Philadelphia)

Abstract

An evolutionarily conserved alveolar epithelial progenitor lineage that derives from alveolar type 2 cells is responsive to Wnt signalling and acts as a major facultative progenitor in regenerating the distal lung.

Suggested Citation

  • William J. Zacharias & David B. Frank & Jarod A. Zepp & Michael P. Morley & Farrah A. Alkhaleel & Jun Kong & Su Zhou & Edward Cantu & Edward E. Morrisey, 2018. "Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor," Nature, Nature, vol. 555(7695), pages 251-255, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7695:d:10.1038_nature25786
    DOI: 10.1038/nature25786
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    Citations

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    Cited by:

    1. Yuanyuan Chen & Reka Toth & Sara Chocarro & Dieter Weichenhan & Joschka Hey & Pavlo Lutsik & Stefan Sawall & Georgios T. Stathopoulos & Christoph Plass & Rocio Sotillo, 2022. "Club cells employ regeneration mechanisms during lung tumorigenesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Laura Heydemann & Małgorzata Ciurkiewicz & Georg Beythien & Kathrin Becker & Klaus Schughart & Stephanie Stanelle-Bertram & Berfin Schaumburg & Nancy Mounogou-Kouassi & Sebastian Beck & Martin Zickler, 2023. "Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Praveen Weeratunga & Laura Denney & Joshua A. Bull & Emmanouela Repapi & Martin Sergeant & Rachel Etherington & Chaitanya Vuppussetty & Gareth D. H. Turner & Colin Clelland & Jeongmin Woo & Amy Cross , 2023. "Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Andrea Toth & Paranthaman Kannan & John Snowball & Matthew Kofron & Joseph A. Wayman & James P. Bridges & Emily R. Miraldi & Daniel Swarr & William J. Zacharias, 2023. "Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Christopher W. Murray & Jennifer J. Brady & Mingqi Han & Hongchen Cai & Min K. Tsai & Sarah E. Pierce & Ran Cheng & Janos Demeter & David M. Feldser & Peter K. Jackson & David B. Shackelford & Monte M, 2022. "LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    6. Xin Pan & Lan Wang & Juntang Yang & Yingge Li & Min Xu & Chenxi Liang & Lulu Liu & Zhongzheng Li & Cong Xia & Jiaojiao Pang & Mengyuan Wang & Meng Li & Saiya Guo & Peishuo Yan & Chen Ding & Ivan O. Ro, 2024. "TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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