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Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

Author

Listed:
  • Andrew E. Vaughan

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Alexis N. Brumwell

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Ying Xi

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Jeffrey E. Gotts

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Doug G. Brownfield

    (Stanford University School of Medicine and Howard Hughes Medical Institute)

  • Barbara Treutlein

    (Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany)

  • Kevin Tan

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Victor Tan

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Feng Chun Liu

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Mark R. Looney

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Michael A. Matthay

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Jason R. Rock

    (School of Medicine, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

  • Harold A. Chapman

    (Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA)

Abstract

Lineage-tracing experiments identify a rare, undifferentiated population of quiescent cells in the mouse distal lung that are activated through a Notch signalling pathway to repair the epithelium after bleomycin- or influenza-mediated injury; inappropriate Notch signalling may be a major contributor to failed regeneration within the lungs of patients with chronic lung disease.

Suggested Citation

  • Andrew E. Vaughan & Alexis N. Brumwell & Ying Xi & Jeffrey E. Gotts & Doug G. Brownfield & Barbara Treutlein & Kevin Tan & Victor Tan & Feng Chun Liu & Mark R. Looney & Michael A. Matthay & Jason R. R, 2015. "Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury," Nature, Nature, vol. 517(7536), pages 621-625, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7536:d:10.1038_nature14112
    DOI: 10.1038/nature14112
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    Cited by:

    1. Yuanyuan Chen & Reka Toth & Sara Chocarro & Dieter Weichenhan & Joschka Hey & Pavlo Lutsik & Stefan Sawall & Georgios T. Stathopoulos & Christoph Plass & Rocio Sotillo, 2022. "Club cells employ regeneration mechanisms during lung tumorigenesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Benedikt Jaeger & Jonas Christian Schupp & Linda Plappert & Oliver Terwolbeck & Nataliia Artysh & Gian Kayser & Peggy Engelhard & Taylor Sterling Adams & Robert Zweigerdt & Henning Kempf & Stefan Lien, 2022. "Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Yue Li & Pengzhen Dong & Yang Yang & Tianyu Guo & Quanyi Zhao & Dan Miao & Huanle Li & Tianfeng Lu & Fanning Xia & Jialan Lyu & Jun Ma & Thomas B. Kornberg & Qiang Zhang & Hai Huang, 2022. "Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Andrew K. Beppu & Juanjuan Zhao & Changfu Yao & Gianni Carraro & Edo Israely & Anna Lucia Coelho & Katherine Drake & Cory M. Hogaboam & William C. Parks & Jay K. Kolls & Barry R. Stripp, 2023. "Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Robert M. Cox & Josef D. Wolf & Nicole A. Lieberman & Carolin M. Lieber & Hae-Ji Kang & Zachary M. Sticher & Jeong-Joong Yoon & Meghan K. Andrews & Mugunthan Govindarajan & Rebecca E. Krueger & Elizab, 2024. "Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Richard J. Hewitt & Franz Puttur & David C. A. Gaboriau & Frédéric Fercoq & Maryline Fresquet & William J. Traves & Laura L. Yates & Simone A. Walker & Philip L. Molyneaux & Samuel V. Kemp & Andrew G., 2023. "Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Laura Heydemann & Małgorzata Ciurkiewicz & Georg Beythien & Kathrin Becker & Klaus Schughart & Stephanie Stanelle-Bertram & Berfin Schaumburg & Nancy Mounogou-Kouassi & Sebastian Beck & Martin Zickler, 2023. "Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    8. Ning Yang & Joseph M. Luna & Peihong Dai & Yi Wang & Charles M. Rice & Liang Deng, 2022. "Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    9. Benjamin Ng & Kevin Y. Huang & Chee Jian Pua & Sivakumar Viswanathan & Wei-Wen Lim & Fathima F. Kuthubudeen & Yu-Ning Liu & An An Hii & Benjamin L. George & Anissa A. Widjaja & Enrico Petretto & Stuar, 2024. "Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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