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Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

Author

Listed:
  • Delphine Goubau

    (Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Martin Schlee

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Safia Deddouche

    (Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    Present addresses: Drosophila Genetics and Epigenetics, Laboratory of Developmental Biology, CNRS UMR7622, Université Pierre et Marie Curie, Paris, France (S.D.); Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK (J.R.).)

  • Andrea J. Pruijssers

    (Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
    Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA)

  • Thomas Zillinger

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Marion Goldeck

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Christine Schuberth

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Annemarthe G. Van der Veen

    (Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Tsutomu Fujimura

    (Instituto de Biología Funcional y Genómica. Consejo Superior de Investigaciones Científicas/Universidad de Salamanca, Zacarías González 2, 37007, Salamanca, Spain)

  • Jan Rehwinkel

    (Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    Present addresses: Drosophila Genetics and Epigenetics, Laboratory of Developmental Biology, CNRS UMR7622, Université Pierre et Marie Curie, Paris, France (S.D.); Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK (J.R.).)

  • Jason A. Iskarpatyoti

    (Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
    Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA)

  • Winfried Barchet

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Janos Ludwig

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Terence S. Dermody

    (Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
    Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA
    Microbiology, and Immunology, Vanderbilt University School of Medicine, D7235 Medical Center North, 1161 21st Avenue South, Nashville, Tennessee 37232-2581, USA)

  • Gunther Hartmann

    (Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany)

  • Caetano Reis e Sousa

    (Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

Abstract

The innate immune receptor RIG-I is shown to sense 5′-diphosphate RNAs as found in some viral genomes in addition to its well characterized activation by RNAs bearing 5′-triphosphate moieties.

Suggested Citation

  • Delphine Goubau & Martin Schlee & Safia Deddouche & Andrea J. Pruijssers & Thomas Zillinger & Marion Goldeck & Christine Schuberth & Annemarthe G. Van der Veen & Tsutomu Fujimura & Jan Rehwinkel & Jas, 2014. "Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates," Nature, Nature, vol. 514(7522), pages 372-375, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7522:d:10.1038_nature13590
    DOI: 10.1038/nature13590
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    Cited by:

    1. Beatrice T. Laudenbach & Karsten Krey & Quirin Emslander & Line Lykke Andersen & Alexander Reim & Pietro Scaturro & Sarah Mundigl & Christopher Dächert & Katrin Manske & Markus Moser & Janos Ludwig & , 2021. "NUDT2 initiates viral RNA degradation by removal of 5′-phosphates," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Qin Yu & Alba Herrero del Valle & Rahul Singh & Yorgo Modis, 2021. "MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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