IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-024-55445-x.html
   My bibliography  Save this article

A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging

Author

Listed:
  • Cheng Yao

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Ruwei Wei

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Xiao Luo

    (East China Normal University)

  • Jie Zhou

    (East China Normal University
    East China Normal University)

  • Xiaodong Zhang

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Xicun Lu

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Yan Dong

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Ruofan Chu

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Yuxin Sun

    (East China University of Science and Technology
    East China University of Science and Technology)

  • Yu Wang

    (East China Normal University)

  • Wencheng Xia

    (Chinese Academy of Sciences)

  • Dahui Qu

    (East China University of Science and Technology)

  • Cong Liu

    (Chinese Academy of Sciences)

  • Jun Ren

    (Hubei University)

  • Guangbo Ge

    (Shanghai University of Traditional Chinese Medicine)

  • Jinquan Chen

    (East China Normal University
    East China Normal University)

  • Xuhong Qian

    (East China University of Science and Technology
    East China University of Science and Technology
    East China Normal University)

  • Youjun Yang

    (East China University of Science and Technology
    East China University of Science and Technology)

Abstract

The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. SWIR spectral activity may also be accessed via supramolecular dye aggregation. Unfortunately, development of dye aggregation remains challenging. We propose a crystal-aided aggregate synthesis (CAASH) approach to introduce a layer of rationality for the development of J-aggregate and the successful development of a water-soluble SWIR JV-aggregate with a bisbenzannulated silicon rhodamine scaffold (ESi5). The resulting SWIR-aggregates exhibit excellent stabilities toward organic solvents, pH, sonication, photobleaching, thiols, and endogenous oxidative species. Notably, the aggregates have a high structure-dependent melting temperature of ca. 330-335 K. In fact, the heating/annealing process can be exploited to reduce aggregation disorder. The aggregates are biocompatible and have broad potential in in vivo fluorescence and photoacoustic imaging and more.

Suggested Citation

  • Cheng Yao & Ruwei Wei & Xiao Luo & Jie Zhou & Xiaodong Zhang & Xicun Lu & Yan Dong & Ruofan Chu & Yuxin Sun & Yu Wang & Wencheng Xia & Dahui Qu & Cong Liu & Jun Ren & Guangbo Ge & Jinquan Chen & Xuhon, 2025. "A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55445-x
    DOI: 10.1038/s41467-024-55445-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-55445-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-55445-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55445-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.