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In situ orderly self-assembly strategy affording NIR-II-J-aggregates for in vivo imaging and surgical navigation

Author

Listed:
  • Zhe Li

    (Hunan University)

  • Ping-Zhao Liang

    (Hunan University)

  • Li Xu

    (Hunan University)

  • Xing-Xing Zhang

    (Hunan University)

  • Ke Li

    (Hunan University)

  • Qian Wu

    (Hunan University)

  • Xiao-Feng Lou

    (Hunan University)

  • Tian-Bing Ren

    (Hunan University)

  • Lin Yuan

    (Hunan University)

  • Xiao-Bing Zhang

    (Hunan University)

Abstract

J-aggregation, an effective strategy to extend wavelength, has been considered as a promising method for constructing NIR-II fluorophores. However, due to weak intermolecular interactions, conventional J-aggregates are easily decomposed into monomers in the biological environment. Although adding external carriers could help conventional J-aggregates stabilize, such methods still suffer from high-concentration dependence and are unsuitable for activatable probes design. Besides, these carriers-assisted nanoparticles are risky of disassembly in lipophilic environment. Herein, by fusing the precipitated dye (HPQ) which has orderly self-assembly structure, onto simple hemi-cyanine conjugated system, we construct a series of activatable, high-stability NIR-II-J-aggregates which overcome conventional J-aggregates carrier’s dependence and could in situ self-assembly in vivo. Further, we employ the NIR-II-J-aggregates probe HPQ-Zzh-B to achieve the long-term in situ imaging of tumor and precise tumor resection by NIR-II imaging navigation for reducing lung metastasis. We believe this strategy will advance the development of controllable NIR-II-J-aggregates and precise bioimaging in vivo.

Suggested Citation

  • Zhe Li & Ping-Zhao Liang & Li Xu & Xing-Xing Zhang & Ke Li & Qian Wu & Xiao-Feng Lou & Tian-Bing Ren & Lin Yuan & Xiao-Bing Zhang, 2023. "In situ orderly self-assembly strategy affording NIR-II-J-aggregates for in vivo imaging and surgical navigation," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37586-7
    DOI: 10.1038/s41467-023-37586-7
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    References listed on IDEAS

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    1. Simona Angerani & Eric Lindberg & Nikolai Klena & Christopher K. E. Bleck & Charlotte Aumeier & Nicolas Winssinger, 2021. "Kinesin-1 activity recorded in living cells with a precipitating dye," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    2. Kang Li & Xingchen Duan & Zhiyong Jiang & Dan Ding & Yuncong Chen & Guo-Qiang Zhang & Zhipeng Liu, 2021. "J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. Yu-Kuan Huang & Minyu Wang & Yu Sun & Natasha Costanzo & Catherine Mitchell & Adrian Achuthan & John A. Hamilton & Rita A. Busuttil & Alex Boussioutas, 2019. "Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
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