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J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Author

Listed:
  • Kang Li

    (Nanjing Forestry University)

  • Xingchen Duan

    (Nankai University)

  • Zhiyong Jiang

    (Nanjing Forestry University)

  • Dan Ding

    (Nankai University)

  • Yuncong Chen

    (Nanjing University)

  • Guo-Qiang Zhang

    (Nankai University)

  • Zhipeng Liu

    (Nanjing Forestry University)

Abstract

J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents.

Suggested Citation

  • Kang Li & Xingchen Duan & Zhiyong Jiang & Dan Ding & Yuncong Chen & Guo-Qiang Zhang & Zhipeng Liu, 2021. "J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22686-z
    DOI: 10.1038/s41467-021-22686-z
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    Cited by:

    1. Zhe Li & Ping-Zhao Liang & Li Xu & Xing-Xing Zhang & Ke Li & Qian Wu & Xiao-Feng Lou & Tian-Bing Ren & Lin Yuan & Xiao-Bing Zhang, 2023. "In situ orderly self-assembly strategy affording NIR-II-J-aggregates for in vivo imaging and surgical navigation," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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