IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v491y2012i7425d10.1038_nature11557.html
   My bibliography  Save this article

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

Author

Listed:
  • Guang-Hui Liu

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Jing Qu

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Keiichiro Suzuki

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Emmanuel Nivet

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Mo Li

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Nuria Montserrat

    (Center for Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain)

  • Fei Yi

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Xiuling Xu

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Sergio Ruiz

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Weiqi Zhang

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • Ulrich Wagner

    (Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine)

  • Audrey Kim

    (Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine)

  • Bing Ren

    (Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine)

  • Ying Li

    (National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences)

  • April Goebl

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Jessica Kim

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Rupa Devi Soligalla

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ilir Dubova

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • James Thompson

    (Scripps Research Institute)

  • John Yates III

    (Scripps Research Institute)

  • Concepcion Rodriguez Esteban

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ignacio Sancho-Martinez

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Juan Carlos Izpisua Belmonte

    (Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Center for Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain)

Abstract

Investigation of neural cells from post-mortem human brains and differentiated from patient-derived induced pluripotent stem cells shows that the LRRK2 mutation (G2019S) associated with familial and sporadic Parkinson's disease correlates with abnormalities at the nuclear envelope.

Suggested Citation

  • Guang-Hui Liu & Jing Qu & Keiichiro Suzuki & Emmanuel Nivet & Mo Li & Nuria Montserrat & Fei Yi & Xiuling Xu & Sergio Ruiz & Weiqi Zhang & Ulrich Wagner & Audrey Kim & Bing Ren & Ying Li & April Goebl, 2012. "Progressive degeneration of human neural stem cells caused by pathogenic LRRK2," Nature, Nature, vol. 491(7425), pages 603-607, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11557
    DOI: 10.1038/nature11557
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11557
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11557?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Baolei Yuan & Xuan Zhou & Keiichiro Suzuki & Gerardo Ramos-Mandujano & Mengge Wang & Muhammad Tehseen & Lorena V. Cortés-Medina & James J. Moresco & Sarah Dunn & Reyna Hernandez-Benitez & Tomoaki Hish, 2022. "Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:491:y:2012:i:7425:d:10.1038_nature11557. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.