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Gustatory interface for operative assessment and taste decoding in patients with tongue cancer

Author

Listed:
  • Xiner Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Guo Bai

    (Chinese Academy of Medical Sciences)

  • Jizhi Liang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Qianyang Xie

    (Chinese Academy of Medical Sciences)

  • Zhaohan Chen

    (Neuroxess Co. Ltd)

  • Erda Zhou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Meng Li

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Xiaoling Wei

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Liuyang Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhiyuan Zhang

    (Chinese Academy of Medical Sciences)

  • Chi Yang

    (Chinese Academy of Medical Sciences)

  • Tiger H. Tao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Neuroxess Co. Ltd
    Chinese Academy of Sciences)

  • Zhitao Zhou

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

Abstract

Taste, a pivotal sense modality, plays a fundamental role in discerning flavors and evaluating the potential harm of food, thereby contributing to human survival, physical and mental health. Patients with tongue cancer may experience a loss of taste following extensive surgical resection with flap reconstruction. Here, we designed a gustatory interface that enables the non-invasive detection of tongue electrical activities for a comprehensive operative assessment. Moreover, it decodes gustatory information from the reconstructed tongue without taste buds. Our gustatory interface facilitates the recording and analysis of electrical activities on the tongue, yielding an electrical mapping across the entire tongue surface, which delineates the safe margin for surgical management and assesses flap viability for postoperative structure monitoring and prompt intervention. Furthermore, the gustatory interface helps patients discern tastes with an accuracy of 97.8%. Our invention offers a promising approach to clinical assessment and management and holds potential for improving the quality of life for individuals with tongue cancer.

Suggested Citation

  • Xiner Wang & Guo Bai & Jizhi Liang & Qianyang Xie & Zhaohan Chen & Erda Zhou & Meng Li & Xiaoling Wei & Liuyang Sun & Zhiyuan Zhang & Chi Yang & Tiger H. Tao & Zhitao Zhou, 2024. "Gustatory interface for operative assessment and taste decoding in patients with tongue cancer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53379-y
    DOI: 10.1038/s41467-024-53379-y
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    References listed on IDEAS

    as
    1. Francis R. Willett & Erin M. Kunz & Chaofei Fan & Donald T. Avansino & Guy H. Wilson & Eun Young Choi & Foram Kamdar & Matthew F. Glasser & Leigh R. Hochberg & Shaul Druckmann & Krishna V. Shenoy & Ja, 2023. "A high-performance speech neuroprosthesis," Nature, Nature, vol. 620(7976), pages 1031-1036, August.
    2. Silvio Abati & Chiara Bramati & Stefano Bondi & Alessandra Lissoni & Matteo Trimarchi, 2020. "Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis," IJERPH, MDPI, vol. 17(24), pages 1-14, December.
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