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Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque

Author

Listed:
  • Joseph Y. Nashed

    (Queen’s University
    Queen’s University)

  • Daniel J. Gale

    (Queen’s University)

  • Jason P. Gallivan

    (Queen’s University
    Queen’s University
    Queen’s University)

  • Douglas J. Cook

    (Queen’s University
    Queen’s University
    Queen’s University)

Abstract

Stroke, a major cause of disability, disrupts brain function and motor skills. Previous research has mainly focused on reorganization of the motor system post-stroke, but the effects on other brain areas and their influence on recovery is poorly understood. Here, we use functional neuroimaging in a nonhuman primate model (23 male Cynomolgus Macaques), we explore how ischemic stroke affects whole-brain cortical architecture and its relation to spontaneous behavioral recovery. By projecting patterns of cortical functional connectivity onto a low-dimensional manifold space, we find that several regions in both sensorimotor cortex and higher-order transmodal cortex exhibit significant shifts in their manifold embedding from pre- to post-stroke. Furthermore, we observe that changes in default mode and limbic network regions, and not preserved sensorimotor cortical regions, are associated with animal behavioral recovery post-stroke. These results establish the whole-brain functional changes associated with stroke, and suggest an important role for higher-order transmodal cortex in post-stroke outcomes.

Suggested Citation

  • Joseph Y. Nashed & Daniel J. Gale & Jason P. Gallivan & Douglas J. Cook, 2024. "Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53365-4
    DOI: 10.1038/s41467-024-53365-4
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    References listed on IDEAS

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