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A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases

Author

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  • Atsuhiro Yasuhara

    (The University of Tokyo)

  • Seiya Yamayoshi

    (The University of Tokyo
    University of Tokyo
    National Center for Global Health and Medicine)

  • Maki Kiso

    (The University of Tokyo)

  • Yuko Sakai-Tagawa

    (The University of Tokyo)

  • Moe Okuda

    (The University of Tokyo)

  • Yoshihiro Kawaoka

    (The University of Tokyo
    University of Tokyo
    National Center for Global Health and Medicine
    University of Wisconsin-Madison)

Abstract

Improved vaccines and antiviral agents that provide better, broader protection against seasonal and emerging influenza viruses are needed. The viral surface glycoprotein hemagglutinin (HA) is a primary target for the development of universal influenza vaccines and therapeutic antibodies. The other major surface antigen, neuraminidase (NA), has been less well studied as a potential target and fewer broadly reactive anti-NA antibodies have been identified. In this study, we isolate three human monoclonal antibodies that recognize NA from A/H1N1 subtypes, and find that one of them, clone DA03E17, binds to the NA of A/H3N2, A/H5N1, A/H7N9, B/Ancestral-lineage, B/Yamagata-lineage, and B/Victoria-lineage viruses. DA03E17 inhibits the neuraminidase activity by direct binding to the enzyme active site, and provides in vitro and in vivo protection against infection with several types of influenza virus. This clone could, therefore, be useful as a broadly protective therapeutic agent. Moreover, the neutralizing epitope of DA03E17 could be useful in the development of an NA-based universal influenza vaccine.

Suggested Citation

  • Atsuhiro Yasuhara & Seiya Yamayoshi & Maki Kiso & Yuko Sakai-Tagawa & Moe Okuda & Yoshihiro Kawaoka, 2022. "A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34521-0
    DOI: 10.1038/s41467-022-34521-0
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    Cited by:

    1. Min Wang & Yuan Gao & Chenguang Shen & Wei Yang & Qi Peng & Jinlong Cheng & Han-Ming Shen & Yang Yang & George Fu Gao & Yi Shi, 2024. "A human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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