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A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

Author

Listed:
  • Dongkyu Kang

    (Hanyang University)

  • Hyung Shik Kim

    (Hanyang University)

  • Soohyun Han

    (Hanyang University)

  • Yeonju Lee

    (Hanyang University)

  • Young-Pil Kim

    (Hanyang University
    Hanyang University
    Hanyang University
    Hanyang University)

  • Dong Yun Lee

    (Hanyang University
    Hanyang University
    Hanyang University
    Elixir Pharmatech Inc.)

  • Joonseok Lee

    (Hanyang University
    Hanyang University)

Abstract

Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this wavelength is considered unsuitable as an imaging and analytical signal in biological environments. However, 1.0 μm NIR can be converted into heat and used as a local water-molecular heating strategy for the photothermal therapy of biological tissues. Herein, we describe a Nd-Yb co-doped nanomaterial (water-heating nanoparticles (NPs)) as strong 1.0 μm emissive NPs to target the absorption band of water. Furthermore, introducing Tm ions into the water-heating NPs improve the NIR lifetime, enabling the development of a NIR imaging-guided water-heating probe (water-heating NIR NPs). In the glioblastoma multiforme male mouse model, tumor-targeted water-heating NIR NPs reduce the tumor volume by 78.9% in the presence of high-resolution intracranial NIR long-lifetime imaging. Hence, water-heating NIR NPs can be used as a promising nanomaterial for imaging and photothermal ablation in deep-tissue-bearing tumor therapy.

Suggested Citation

  • Dongkyu Kang & Hyung Shik Kim & Soohyun Han & Yeonju Lee & Young-Pil Kim & Dong Yun Lee & Joonseok Lee, 2023. "A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38451-3
    DOI: 10.1038/s41467-023-38451-3
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