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Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment

Author

Listed:
  • Liangyu Li

    (Beijing University of Chemical Technology)

  • Xiaotong Liu

    (Beijing University of Chemical Technology)

  • Guanghe Liu

    (Beijing University of Chemical Technology)

  • Suying Xu

    (Beijing University of Chemical Technology)

  • Gaofei Hu

    (Beijing University of Chemical Technology)

  • Leyu Wang

    (Beijing University of Chemical Technology)

Abstract

The optimization of the enzyme-like catalytic selectivity of nanozymes for specific reactive oxygen species (ROS)-related applications is significant, and meanwhile the real-time monitoring of ROS is really crucial for tracking the therapeutic process. Herein, we present a mild oxidation valence-engineering strategy to modulate the valence states of Mo in Pluronic F127-coated MoO3-x nanozymes (denoted as MF-x, x: oxidation time) in a controlled manner aiming to improve their specificity of H2O2-associated catalytic reactions for specific therapy and monitoring of ROS-related diseases. Experimentally, MF-0 (Mo average valence 4.64) and MF-10 (Mo average valence 5.68) exhibit exclusively optimal catalase (CAT)- or peroxidase (POD)-like activity, respectively. Density functional theory (DFT) calculations verify the most favorable reaction path for both MF-0- and MF-10-catalyzed reaction processes based on free energy diagram and electronic structure analysis, disclosing the mechanism of the H2O2 activation pathway on the Mo-based nanozymes. Furthermore, MF-0 poses a strong potential in acute kidney injury (AKI) treatment, achieving excellent therapeutic outcomes in vitro and in vivo. Notably, the ROS-responsive photoacoustic imaging (PAI) signal of MF-0 during treatment guarantees real-time monitoring of the therapeutic effect and post-cure assessment in vivo, providing a highly desirable non-invasive diagnostic approach for ROS-related diseases.

Suggested Citation

  • Liangyu Li & Xiaotong Liu & Guanghe Liu & Suying Xu & Gaofei Hu & Leyu Wang, 2024. "Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53047-1
    DOI: 10.1038/s41467-024-53047-1
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    1. Qinjie Weng & Heng Sun & Chunyan Fang & Fan Xia & Hongwei Liao & Jiyoung Lee & Jincheng Wang & An Xie & Jiafeng Ren & Xia Guo & Fangyuan Li & Bo Yang & Daishun Ling, 2021. "Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Tengfei Liu & Bowen Xiao & Fei Xiang & Jianglin Tan & Zhuo Chen & Xiaorong Zhang & Chengzhou Wu & Zhengwei Mao & Gaoxing Luo & Xiaoyuan Chen & Jun Deng, 2020. "Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    3. Ge Fang & Weifeng Li & Xiaomei Shen & Jose Manuel Perez-Aguilar & Yu Chong & Xingfa Gao & Zhifang Chai & Chunying Chen & Cuicui Ge & Ruhong Zhou, 2018. "Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
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