IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-35868-8.html
   My bibliography  Save this article

Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury

Author

Listed:
  • Biao Huang

    (Wuhan University)

  • Tao Tang

    (Wuhan University of Technology)

  • Shi-Hui Chen

    (Wuhan University)

  • Hao Li

    (Wuhan University)

  • Zhi-Jun Sun

    (Wuhan University)

  • Zhi-Lin Zhang

    (Wuhan University)

  • Mingxi Zhang

    (Wuhan University of Technology)

  • Ran Cui

    (Wuhan University)

Abstract

The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury, always triggers a cascade of biochemical events like inflammatory response and free radical-mediated oxidative damage, leading to neurological dysfunction. The dynamic monitoring the status of blood-brain barrier will provide potent guidance for adopting appropriate clinical intervention. Here, we engineer a near-infrared-IIb Ag2Te quantum dot-based Mn single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown of mice after traumatic brain injury. The dynamic change of blood-brain barrier, including the transient cerebral hypoperfusion and cerebrovascular damage, could be resolved with high spatiotemporal resolution (150 ms and ~ 9.6 µm). Notably, the isolated single Mn atoms on the surface of Ag2Te exhibited excellent catalytic activity for scavenging reactive oxygen species to alleviate neuroinflammation in brains. The timely injection of Mn single-atom catalyst guided by imaging significantly promoted the reconstruction of blood-brain barrier and recovery of neurological function after traumatic brain injury.

Suggested Citation

  • Biao Huang & Tao Tang & Shi-Hui Chen & Hao Li & Zhi-Jun Sun & Zhi-Lin Zhang & Mingxi Zhang & Ran Cui, 2023. "Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35868-8
    DOI: 10.1038/s41467-023-35868-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-35868-8
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-35868-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tengfei Liu & Bowen Xiao & Fei Xiang & Jianglin Tan & Zhuo Chen & Xiaorong Zhang & Chengzhou Wu & Zhengwei Mao & Gaoxing Luo & Xiaoyuan Chen & Jun Deng, 2020. "Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Hao Li & Meng Wang & Biao Huang & Su-Wen Zhu & Jun-Jie Zhou & De-Run Chen & Ran Cui & Mingxi Zhang & Zhi-Jun Sun, 2021. "Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Haile Liu & Yonghui Li & Si Sun & Qi Xin & Shuhu Liu & Xiaoyu Mu & Xun Yuan & Ke Chen & Hao Wang & Kalman Varga & Wenbo Mi & Jiang Yang & Xiao-Dong Zhang, 2021. "Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Wei Feng & Xiuguo Han & Hui Hu & Meiqi Chang & Li Ding & Huijing Xiang & Yu Chen & Yuehua Li, 2021. "2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Penghong Liu & Zhifen Liu & Jizhi Wang & Junyan Wang & Mingxue Gao & Yanyan Zhang & Chunxia Yang & Aixia Zhang & Gaizhi Li & Xinrong Li & Sha Liu & Lixin Liu & Ning Sun & Kerang Zhang, 2024. "Immunoregulatory role of the gut microbiota in inflammatory depression," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kaiyuan Wang & Qing Hong & Caixia Zhu & Yuan Xu & Wang Li & Ying Wang & Wenhao Chen & Xiang Gu & Xinghua Chen & Yanfeng Fang & Yanfei Shen & Songqin Liu & Yuanjian Zhang, 2024. "Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Ke Chen & Guo Li & Xiaoqun Gong & Qinjuan Ren & Junying Wang & Shuang Zhao & Ling Liu & Yuxing Yan & Qingshan Liu & Yang Cao & Yaoyao Ren & Qiong Qin & Qi Xin & Shu-Lin Liu & Peiyu Yao & Bo Zhang & Ji, 2024. "Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Liangyu Li & Xiaotong Liu & Guanghe Liu & Suying Xu & Gaofei Hu & Leyu Wang, 2024. "Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Yulei Chang & Haoren Chen & Xiaoyu Xie & Yong Wan & Qiqing Li & Fengxia Wu & Run Yang & Wang Wang & Xianggui Kong, 2023. "Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    5. Kaiyuan Wang & Yang Li & Xia Wang & Zhijun Zhang & Liping Cao & Xiaoyuan Fan & Bin Wan & Fengxiang Liu & Xuanbo Zhang & Zhonggui He & Yingtang Zhou & Dong Wang & Jin Sun & Xiaoyuan Chen, 2023. "Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Shaofang Zhang & Yonghui Li & Si Sun & Ling Liu & Xiaoyu Mu & Shuhu Liu & Menglu Jiao & Xinzhu Chen & Ke Chen & Huizhen Ma & Tuo Li & Xiaoyu Liu & Hao Wang & Jianning Zhang & Jiang Yang & Xiao-Dong Zh, 2022. "Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35868-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.