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Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury

Author

Listed:
  • Biao Huang

    (Wuhan University)

  • Tao Tang

    (Wuhan University of Technology)

  • Shi-Hui Chen

    (Wuhan University)

  • Hao Li

    (Wuhan University)

  • Zhi-Jun Sun

    (Wuhan University)

  • Zhi-Lin Zhang

    (Wuhan University)

  • Mingxi Zhang

    (Wuhan University of Technology)

  • Ran Cui

    (Wuhan University)

Abstract

The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury, always triggers a cascade of biochemical events like inflammatory response and free radical-mediated oxidative damage, leading to neurological dysfunction. The dynamic monitoring the status of blood-brain barrier will provide potent guidance for adopting appropriate clinical intervention. Here, we engineer a near-infrared-IIb Ag2Te quantum dot-based Mn single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown of mice after traumatic brain injury. The dynamic change of blood-brain barrier, including the transient cerebral hypoperfusion and cerebrovascular damage, could be resolved with high spatiotemporal resolution (150 ms and ~ 9.6 µm). Notably, the isolated single Mn atoms on the surface of Ag2Te exhibited excellent catalytic activity for scavenging reactive oxygen species to alleviate neuroinflammation in brains. The timely injection of Mn single-atom catalyst guided by imaging significantly promoted the reconstruction of blood-brain barrier and recovery of neurological function after traumatic brain injury.

Suggested Citation

  • Biao Huang & Tao Tang & Shi-Hui Chen & Hao Li & Zhi-Jun Sun & Zhi-Lin Zhang & Mingxi Zhang & Ran Cui, 2023. "Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35868-8
    DOI: 10.1038/s41467-023-35868-8
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    References listed on IDEAS

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    1. Haile Liu & Yonghui Li & Si Sun & Qi Xin & Shuhu Liu & Xiaoyu Mu & Xun Yuan & Ke Chen & Hao Wang & Kalman Varga & Wenbo Mi & Jiang Yang & Xiao-Dong Zhang, 2021. "Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Wei Feng & Xiuguo Han & Hui Hu & Meiqi Chang & Li Ding & Huijing Xiang & Yu Chen & Yuehua Li, 2021. "2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. Tengfei Liu & Bowen Xiao & Fei Xiang & Jianglin Tan & Zhuo Chen & Xiaorong Zhang & Chengzhou Wu & Zhengwei Mao & Gaoxing Luo & Xiaoyuan Chen & Jun Deng, 2020. "Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    4. Hao Li & Meng Wang & Biao Huang & Su-Wen Zhu & Jun-Jie Zhou & De-Run Chen & Ran Cui & Mingxi Zhang & Zhi-Jun Sun, 2021. "Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
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    1. Penghong Liu & Zhifen Liu & Jizhi Wang & Junyan Wang & Mingxue Gao & Yanyan Zhang & Chunxia Yang & Aixia Zhang & Gaizhi Li & Xinrong Li & Sha Liu & Lixin Liu & Ning Sun & Kerang Zhang, 2024. "Immunoregulatory role of the gut microbiota in inflammatory depression," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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