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Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Author

Listed:
  • Qinjie Weng

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Heng Sun

    (Zhejiang University
    Zhejiang University)

  • Chunyan Fang

    (Zhejiang University
    Zhejiang University)

  • Fan Xia

    (Zhejiang University
    Zhejiang University)

  • Hongwei Liao

    (Zhejiang University)

  • Jiyoung Lee

    (Zhejiang University)

  • Jincheng Wang

    (Zhejiang University
    Zhejiang University)

  • An Xie

    (Zhejiang University
    Zhejiang University)

  • Jiafeng Ren

    (Zhejiang University
    Zhejiang University)

  • Xia Guo

    (Zhejiang University
    Zhejiang University)

  • Fangyuan Li

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Bo Yang

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Daishun Ling

    (Zhejiang University
    Zhejiang University
    Zhejiang University
    Shanghai Jiao Tong University)

Abstract

Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer patients receiving chemotherapy. It is correlated with the collateral damage to renal cells caused by reactive oxygen species (ROS). Currently, ROS management is a practical strategy that can reduce the risk of chemotherapy-related AKI, but at the cost of chemotherapeutic efficacy. Herein, we report catalytic activity tunable ceria nanoparticles (CNPs) that can prevent chemotherapy-induced AKI without interference with chemotherapeutic agents. Specifically, in the renal cortex, CNPs exhibit catalytic activity that decomposes hydrogen peroxide, and subsequently regulate the ROS-involved genes by activating the Nrf2/Keap1 signaling pathway. These restore the redox homeostasis for the protection of kidney tubules. Under an acidic tumor microenvironment, CNPs become inert due to the excessive H+ that disrupts the re-exposure of active catalytic sites, allowing a buildup of chemotherapy-mediated ROS generation to kill cancer cells. As ROS-modulating agents, CNPs incorporated with context-dependent catalytic activity, hold a great potential for clinical prevention and treatment of AKI in cancer patients.

Suggested Citation

  • Qinjie Weng & Heng Sun & Chunyan Fang & Fan Xia & Hongwei Liao & Jiyoung Lee & Jincheng Wang & An Xie & Jiafeng Ren & Xia Guo & Fangyuan Li & Bo Yang & Daishun Ling, 2021. "Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21714-2
    DOI: 10.1038/s41467-021-21714-2
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    Cited by:

    1. Chi Yao & Yuwei Xu & Jianpu Tang & Pin Hu & Hedong Qi & Dayong Yang, 2022. "Dynamic assembly of DNA-ceria nanocomplex in living cells generates artificial peroxisome," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Jie Cai & Jie Peng & Juan Feng & Ruocheng Li & Peng Ren & Xinwei Zang & Zezong Wu & Yi Lu & Lin Luo & Zhenzhen Hu & Jiaying Wang & Xiaomeng Dai & Peng Zhao & Juan Wang & Mi Yan & Jianxin Liu & Renren , 2023. "Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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