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The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing

Author

Listed:
  • Dongqing Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhuang Liu

    (Karolinska Institutet)

  • Letian Zhang

    (Karolinska Institutet)

  • Xiaowei Bian

    (Karolinska Institutet)

  • Jianmin Wu

    (Wenzhou Medical University)

  • Li Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yongjian Chen

    (Karolinska Institutet)

  • Lihua Luo

    (Karolinska Institutet)

  • Ling Pan

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Lingzhuo Kong

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yunting Xiao

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jiating Wang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Xiya Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Wang Wang

    (East China Normal University)

  • Maria Toma

    (Karolinska Institutet)

  • Minna Piipponen

    (Karolinska Institutet)

  • Pehr Sommar

    (Karolinska University Hospital)

  • Ning Xu Landén

    (Karolinska Institutet)

Abstract

The cell transition from an inflammatory phase to a subsequent proliferative phase is crucial for wound healing, yet the driving mechanism remains unclear. By profiling lncRNA expression changes during human skin wound healing and screening lncRNA functions, we identify SNHG26 as a pivotal regulator in keratinocyte progenitors underpinning this phase transition. Snhg26-deficient mice exhibit impaired wound repair characterized by delayed re-epithelization accompanied by exacerbated inflammation. Single-cell transcriptome analysis combined with gain-of-function and loss-of-function of SNHG26 in vitro and ex vivo reveals its specific role in facilitating inflammatory-to-proliferative state transition of keratinocyte progenitors. A mechanistic study unravels that SNHG26 interacts with and relocates the transcription factor ILF2 from inflammatory genomic loci, such as JUN, IL6, IL8, and CCL20, to the genomic locus of LAMB3. Collectively, our findings suggest that lncRNAs play cardinal roles in expediting tissue repair and regeneration and may constitute an invaluable reservoir of therapeutic targets in reparative medicine.

Suggested Citation

  • Dongqing Li & Zhuang Liu & Letian Zhang & Xiaowei Bian & Jianmin Wu & Li Li & Yongjian Chen & Lihua Luo & Ling Pan & Lingzhuo Kong & Yunting Xiao & Jiating Wang & Xiya Zhang & Wang Wang & Maria Toma &, 2024. "The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52783-8
    DOI: 10.1038/s41467-024-52783-8
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