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Control of somatic tissue differentiation by the long non-coding RNA TINCR

Author

Listed:
  • Markus Kretz

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Zurab Siprashvili

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Ci Chu

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Dan E. Webster

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Ashley Zehnder

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Kun Qu

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Carolyn S. Lee

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Ross J. Flockhart

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Abigail F. Groff

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Jennifer Chow

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Danielle Johnston

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Grace E. Kim

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Robert C. Spitale

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Ryan A. Flynn

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Grace X. Y. Zheng

    (The Program in Epithelial Biology, Stanford University School of Medicine)

  • Subhadra Aiyer

    (University of Pennsylvania)

  • Arjun Raj

    (University of Pennsylvania)

  • John L. Rinn

    (Harvard University)

  • Howard Y. Chang

    (The Program in Epithelial Biology, Stanford University School of Medicine
    Howard Hughes Medical Institute)

  • Paul A. Khavari

    (The Program in Epithelial Biology, Stanford University School of Medicine
    Veterans Affairs Palo Alto Healthcare System)

Abstract

The human long non-coding RNA TINCR binds to STAU1 and controls epidermal differentiation by stabilizing key differentiation mRNAs, by means of a TINCR-binding motif found enriched in epidermal differentiation genes.

Suggested Citation

  • Markus Kretz & Zurab Siprashvili & Ci Chu & Dan E. Webster & Ashley Zehnder & Kun Qu & Carolyn S. Lee & Ross J. Flockhart & Abigail F. Groff & Jennifer Chow & Danielle Johnston & Grace E. Kim & Robert, 2013. "Control of somatic tissue differentiation by the long non-coding RNA TINCR," Nature, Nature, vol. 493(7431), pages 231-235, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11661
    DOI: 10.1038/nature11661
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    Cited by:

    1. Peter Bailey & Rachel A. Ridgway & Patrizia Cammareri & Mairi Treanor-Taylor & Ulla-Maja Bailey & Christina Schoenherr & Max Bone & Daniel Schreyer & Karin Purdie & Jason Thomson & William Rickaby & R, 2023. "Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Lihui Liu & Ziyang Liu & Qinghua Liu & Wei Wu & Peng Lin & Xing Liu & Yuechuan Zhang & Dongpeng Wang & Briana C. Prager & Ryan C. Gimple & Jichuan Yu & Weixi Zhao & Qiulian Wu & Wei Zhang & Erzhong Wu, 2023. "LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Lucia Morgado-Palacin & Jessie A. Brown & Thomas F. Martinez & Juana M. Garcia-Pedrero & Farhad Forouhar & S. Aidan Quinn & Clara Reglero & Joan Vaughan & Yasamin Hajy Heydary & Cynthia Donaldson & Sa, 2023. "The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Olga Boix & Marion Martinez & Santiago Vidal & Marta Giménez-Alejandre & Lluís Palenzuela & Laura Lorenzo-Sanz & Laura Quevedo & Olivier Moscoso & Jorge Ruiz-Orera & Pilar Ximénez-Embún & Nikaoly Ciri, 2022. "pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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