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Potent pollen gene regulation by DNA glycosylases in maize

Author

Listed:
  • Yibing Zeng

    (University of Georgia)

  • Julian Somers

    (University of Georgia)

  • Harrison S. Bell

    (Oregon State University)

  • Zuzana Vejlupkova

    (Oregon State University)

  • R. Kelly Dawe

    (University of Georgia
    University of Georgia)

  • John E. Fowler

    (Oregon State University)

  • Brad Nelms

    (University of Georgia)

  • Jonathan I. Gent

    (University of Georgia)

Abstract

Although DNA methylation primarily represses TEs, it also represses select genes that are methylated in plant body tissues but demethylated by DNA glycosylases (DNGs) in endosperm or pollen. Either one of two DNGs, MATERNAL DEREPRESSION OF R1 (MDR1) or DNG102, is essential for pollen viability in maize. Using single-pollen mRNA sequencing on pollen-segregating mutations in both genes, we identify 58 candidate DNG target genes that account for 11.1% of the wild-type transcriptome but are silent or barely detectable in other tissues. They are unusual in their tendency to lack introns but even more so in their TE-like methylation (teM) in coding DNA. The majority have predicted functions in cell wall modification, and they likely support the rapid tip growth characteristic of pollen tubes. These results suggest a critical role for DNA methylation and demethylation in regulating maize genes with the potential for extremely high expression in pollen but constitutive silencing elsewhere.

Suggested Citation

  • Yibing Zeng & Julian Somers & Harrison S. Bell & Zuzana Vejlupkova & R. Kelly Dawe & John E. Fowler & Brad Nelms & Jonathan I. Gent, 2024. "Potent pollen gene regulation by DNA glycosylases in maize," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52620-y
    DOI: 10.1038/s41467-024-52620-y
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    References listed on IDEAS

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    1. Yinping Jiao & Paul Peluso & Jinghua Shi & Tiffany Liang & Michelle C. Stitzer & Bo Wang & Michael S. Campbell & Joshua C. Stein & Xuehong Wei & Chen-Shan Chin & Katherine Guill & Michael Regulski & S, 2017. "Improved maize reference genome with single-molecule technologies," Nature, Nature, vol. 546(7659), pages 524-527, June.
    2. Robert J. Schmitz & Matthew D. Schultz & Mark A. Urich & Joseph R. Nery & Mattia Pelizzola & Ondrej Libiger & Andrew Alix & Richard B. McCosh & Huaming Chen & Nicholas J. Schork & Joseph R. Ecker, 2013. "Patterns of population epigenomic diversity," Nature, Nature, vol. 495(7440), pages 193-198, March.
    3. Souraya Khouider & Filipe Borges & Chantal LeBlanc & Alexander Ungru & Arp Schnittger & Robert Martienssen & Vincent Colot & Daniel Bouyer, 2021. "Male fertility in Arabidopsis requires active DNA demethylation of genes that control pollen tube function," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
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