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HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis

Author

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  • Yasuhito Sakuraba

    (The University of Tokyo, Yayoi 1-1-1)

  • Mailun Yang

    (The University of Tokyo, Yayoi 1-1-1)

  • Shuichi Yanagisawa

    (The University of Tokyo, Yayoi 1-1-1)

Abstract

Nitrogen (N) deficiency responses are essential for plant survival and reproduction. Here, via an expression genome-wide association study (eGWAS), we reveal a mechanism that regulates microRNA (miRNA) dynamics necessary for N deficiency responses in Arabidopsis. Differential expression levels of three NAC transcription factor (TF) genes involved in leaf N deficiency responses among Arabidopsis accessions are most significantly associated with polymorphisms in HASTY (HST), which encodes an importin/exportin family protein responsible for the generation of mature miRNAs. HST acts as a negative regulator of N deficiency-induced leaf senescence, and the disruption and overexpression of HST differently modifies miRNA dynamics in response to N deficiency, altering levels of miRNAs targeting transcripts. Interestingly, N deficiency prevents the interaction of HST with HST-interacting proteins, DCL1 and RAN1, and some miRNAs. This suggests that HST-mediated regulation of miRNA dynamics collectively controls regulations mediated by multiple N deficiency response-associated NAC TFs, thereby being central to the N deficiency response network.

Suggested Citation

  • Yasuhito Sakuraba & Mailun Yang & Shuichi Yanagisawa, 2024. "HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52339-w
    DOI: 10.1038/s41467-024-52339-w
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    References listed on IDEAS

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    1. Yoshie Maeda & Mineko Konishi & Takatoshi Kiba & Yasuhito Sakuraba & Naoya Sawaki & Tomohiro Kurai & Yoshiaki Ueda & Hitoshi Sakakibara & Shuichi Yanagisawa, 2018. "A NIGT1-centred transcriptional cascade regulates nitrate signalling and incorporates phosphorus starvation signals in Arabidopsis," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    2. Zhongtao Jia & Ricardo F. H. Giehl & Nicolaus von Wirén, 2021. "Local auxin biosynthesis acts downstream of brassinosteroids to trigger root foraging for nitrogen," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Byoung-Doo Lee & Mi Ri Kim & Min-Young Kang & Joon-Yung Cha & Su-Hyun Han & Ganesh M. Nawkar & Yasuhito Sakuraba & Sang Yeol Lee & Takato Imaizumi & C. Robertson McClung & Woe-Yeon Kim & Nam-Chon Paek, 2017. "The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
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