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The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering

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  • Byoung-Doo Lee

    (Seoul National University)

  • Mi Ri Kim

    (Gyeongsang National University)

  • Min-Young Kang

    (Seoul National University)

  • Joon-Yung Cha

    (Gyeongsang National University)

  • Su-Hyun Han

    (Seoul National University)

  • Ganesh M. Nawkar

    (Gyeongsang National University)

  • Yasuhito Sakuraba

    (Seoul National University)

  • Sang Yeol Lee

    (Gyeongsang National University)

  • Takato Imaizumi

    (University of Washington)

  • C. Robertson McClung

    (Dartmouth College)

  • Woe-Yeon Kim

    (Gyeongsang National University)

  • Nam-Chon Paek

    (Seoul National University)

Abstract

In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING, KELCH REPEAT, F-BOX1 (FKF1) interacts with CO and stabilizes it by an unknown mechanism. Here, we provide genetic and biochemical evidence that FKF1 inhibits CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)-dependent CO degradation. Light-activated FKF1 has no apparent effect on COP1 stability but can interact with and negatively regulate COP1. We show that FKF1 can inhibit COP1 homo-dimerization. Mutation of the coiled-coil domain in COP1, which prevents dimer formation, impairs COP1 function in coordinating flowering time. Based on these results, we propose a model whereby the light- and day length-dependent interaction between FKF1 and COP1 controls CO stability to regulate flowering time.

Suggested Citation

  • Byoung-Doo Lee & Mi Ri Kim & Min-Young Kang & Joon-Yung Cha & Su-Hyun Han & Ganesh M. Nawkar & Yasuhito Sakuraba & Sang Yeol Lee & Takato Imaizumi & C. Robertson McClung & Woe-Yeon Kim & Nam-Chon Paek, 2017. "The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02476-2
    DOI: 10.1038/s41467-017-02476-2
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    Cited by:

    1. Yasuhito Sakuraba & Mailun Yang & Shuichi Yanagisawa, 2024. "HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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