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A NIGT1-centred transcriptional cascade regulates nitrate signalling and incorporates phosphorus starvation signals in Arabidopsis

Author

Listed:
  • Yoshie Maeda

    (The University of Tokyo)

  • Mineko Konishi

    (The University of Tokyo)

  • Takatoshi Kiba

    (RIKEN Center for Sustainable Resource Science)

  • Yasuhito Sakuraba

    (The University of Tokyo)

  • Naoya Sawaki

    (The University of Tokyo)

  • Tomohiro Kurai

    (The University of Tokyo)

  • Yoshiaki Ueda

    (The University of Tokyo)

  • Hitoshi Sakakibara

    (RIKEN Center for Sustainable Resource Science)

  • Shuichi Yanagisawa

    (The University of Tokyo)

Abstract

Nitrate is a nutrient signal that triggers complex regulation of transcriptional networks to modulate nutrient-dependent growth and development in plants. This includes time- and nitrate concentration-dependent regulation of nitrate-related gene expression. However, the underlying mechanisms remain poorly understood. Here we identify NIGT1 transcriptional repressors as negative regulators of the Arabidopsis NRT2.1 nitrate transporter gene, and show antagonistic regulation by NLP primary transcription factors for nitrate signalling and the NLP-NIGT1 transcriptional cascade-mediated repression. This antagonistic regulation provides a resolution to the complexity of nitrate-induced transcriptional regulations. Genome-wide analysis reveals that this mechanism is applicable to NRT2.1 and other genes involved in nitrate assimilation, hormone biosynthesis and transcription. Furthermore, the PHR1 master regulator of the phosphorus-starvation response also directly promotes expression of NIGT1 family genes, leading to reductions in nitrate uptake. NIGT1 repressors thus act in two transcriptional cascades, forming a direct link between phosphorus and nitrogen nutritional regulation.

Suggested Citation

  • Yoshie Maeda & Mineko Konishi & Takatoshi Kiba & Yasuhito Sakuraba & Naoya Sawaki & Tomohiro Kurai & Yoshiaki Ueda & Hitoshi Sakakibara & Shuichi Yanagisawa, 2018. "A NIGT1-centred transcriptional cascade regulates nitrate signalling and incorporates phosphorus starvation signals in Arabidopsis," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03832-6
    DOI: 10.1038/s41467-018-03832-6
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    Cited by:

    1. Kei Hiruma & Seishiro Aoki & Junya Takino & Takeshi Higa & Yuniar Devi Utami & Akito Shiina & Masanori Okamoto & Masami Nakamura & Nanami Kawamura & Yoshihiro Ohmori & Ryohei Sugita & Keitaro Tanoi & , 2023. "A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Jieshun Lin & Yuda Purwana Roswanjaya & Wouter Kohlen & Jens Stougaard & Dugald Reid, 2021. "Nitrate restricts nodule organogenesis through inhibition of cytokinin biosynthesis in Lotus japonicus," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Pierre Gautrat & Sara Buti & Andrés Romanowski & Michiel Lammers & Sanne E. A. Matton & Guido Buijs & Ronald Pierik, 2024. "Phytochrome-dependent responsiveness to root-derived cytokinins enables coordinated elongation responses to combined light and nitrate cues," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Yasuhito Sakuraba & Mailun Yang & Shuichi Yanagisawa, 2024. "HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Sanghwa Lee & Julia Showalter & Ling Zhang & Gaëlle Cassin-Ross & Hatem Rouached & Wolfgang Busch, 2024. "Nutrient levels control root growth responses to high ambient temperature in plants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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