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Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system

Author

Listed:
  • Christopher N. Takahashi

    (University of Washington)

  • David P. Ward

    (University of Washington)

  • Carlo Cazzaniga

    (Science and Technology Facilities Council)

  • Christopher Frost

    (Science and Technology Facilities Council)

  • Paolo Rech

    (University of Trento)

  • Kumkum Ganguly

    (Los Alamos National Laboratory)

  • Sean Blanchard

    (Los Alamos National Laboratory)

  • Steve Wender

    (Los Alamos National Laboratory)

  • Bichlien H. Nguyen

    (University of Washington
    Microsoft Research)

  • Jake A. Smith

    (University of Washington
    Microsoft Research)

Abstract

DNA data storage is a potential alternative to magnetic tape for archival storage purposes, promising substantial gains in information density. Critical to the success of DNA as a storage media is an understanding of the role of environmental factors on the longevity of the stored information. In this paper, we evaluate the effect of exposure to ionizing particle radiation, a cause of data loss in traditional magnetic media, on the longevity of data in DNA data storage pools. We develop a mass action kinetics model to estimate the rate of damage accumulation in DNA strands due to neutron interactions with both nucleotides and residual water molecules, then utilize the model to evaluate the effect several design parameters of a typical DNA data storage scheme have on expected data longevity. Finally, we experimentally validate our model by exposing dried DNA samples to different levels of neutron irradiation and analyzing the resulting error profile. Our results show that particle radiation is not a significant contributor to data loss in DNA data storage pools under typical storage conditions.

Suggested Citation

  • Christopher N. Takahashi & David P. Ward & Carlo Cazzaniga & Christopher Frost & Paolo Rech & Kumkum Ganguly & Sean Blanchard & Steve Wender & Bichlien H. Nguyen & Jake A. Smith, 2024. "Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51768-x
    DOI: 10.1038/s41467-024-51768-x
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    References listed on IDEAS

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    1. Adeolu B. Adewoye & Sarah J. Lindsay & Yuri E. Dubrova & Matthew E. Hurles, 2015. "The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
    2. Lee Organick & Yuan-Jyue Chen & Siena Dumas Ang & Randolph Lopez & Xiaomeng Liu & Karin Strauss & Luis Ceze, 2020. "Probing the physical limits of reliable DNA data retrieval," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    3. Nick Goldman & Paul Bertone & Siyuan Chen & Christophe Dessimoz & Emily M. LeProust & Botond Sipos & Ewan Birney, 2013. "Towards practical, high-capacity, low-maintenance information storage in synthesized DNA," Nature, Nature, vol. 494(7435), pages 77-80, February.
    4. Lee Organick & Yuan-Jyue Chen & Siena Dumas Ang & Randolph Lopez & Xiaomeng Liu & Karin Strauss & Luis Ceze, 2020. "Author Correction: Probing the physical limits of reliable DNA data retrieval," Nature Communications, Nature, vol. 11(1), pages 1-1, December.
    5. Karishma Matange & James M. Tuck & Albert J. Keung, 2021. "DNA stability: a central design consideration for DNA data storage systems," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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