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DNA stability: a central design consideration for DNA data storage systems

Author

Listed:
  • Karishma Matange

    (North Carolina State University)

  • James M. Tuck

    (North Carolina State University)

  • Albert J. Keung

    (North Carolina State University)

Abstract

Data storage in DNA is a rapidly evolving technology that could be a transformative solution for the rising energy, materials, and space needs of modern information storage. Given that the information medium is DNA itself, its stability under different storage and processing conditions will fundamentally impact and constrain design considerations and data system capabilities. Here we analyze the storage conditions, molecular mechanisms, and stabilization strategies influencing DNA stability and pose specific design configurations and scenarios for future systems that best leverage the considerable advantages of DNA storage.

Suggested Citation

  • Karishma Matange & James M. Tuck & Albert J. Keung, 2021. "DNA stability: a central design consideration for DNA data storage systems," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21587-5
    DOI: 10.1038/s41467-021-21587-5
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    Cited by:

    1. Lifu Song & Feng Geng & Zi-Yi Gong & Xin Chen & Jijun Tang & Chunye Gong & Libang Zhou & Rui Xia & Ming-Zhe Han & Jing-Yi Xu & Bing-Zhi Li & Ying-Jin Yuan, 2022. "Robust data storage in DNA by de Bruijn graph-based de novo strand assembly," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Afsaneh Sadremomtaz & Robert F. Glass & Jorge Eduardo Guerrero & Dennis R. LaJeunesse & Eric A. Josephs & Reza Zadegan, 2023. "Digital data storage on DNA tape using CRISPR base editors," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Marius Welzel & Peter Michael Schwarz & Hannah F. Löchel & Tolganay Kabdullayeva & Sandra Clemens & Anke Becker & Bernd Freisleben & Dominik Heider, 2023. "DNA-Aeon provides flexible arithmetic coding for constraint adherence and error correction in DNA storage," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Adam Kuzdraliński & Marek Miśkiewicz & Hubert Szczerba & Wojciech Mazurczyk & Jeff Nivala & Bogdan Księżopolski, 2023. "Unlocking the potential of DNA-based tagging: current market solutions and expanding horizons," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    5. Christopher N. Takahashi & David P. Ward & Carlo Cazzaniga & Christopher Frost & Paolo Rech & Kumkum Ganguly & Sean Blanchard & Steve Wender & Bichlien H. Nguyen & Jake A. Smith, 2024. "Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    6. Ruohong Shi & Kuan-Lin Chen & Joshua Fern & Siming Deng & Yixin Liu & Dominic Scalise & Qi Huang & Noah J. Cowan & David H. Gracias & Rebecca Schulman, 2024. "Programming gel automata shapes using DNA instructions," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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