Author
Listed:
- Hong-Yan Wang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Jian-Yang Chen
(BGI Research
BGI Research)
- Yanan Li
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center
Shanghai Ocean University)
- Xianghui Zhang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Xiang Liu
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center
BGI Research)
- Yifang Lu
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Hang He
(BGI Research
BGI Research)
- Yubang Li
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Hongxi Chen
(BGI Research
BGI Research)
- Qun Liu
(BGI Research
BGI Research)
- Yingyi Huang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Zhao Jia
(Shanghai Ocean University)
- Shuo Li
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Yangqing Zhang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Shenglei Han
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Shuhong Jiang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Mingming Yang
(BGI Research
BGI Research)
- Yingying Zhang
(BGI Research
BGI Research)
- Li Zhou
(BGI Research
BGI Research)
- Fujian Tan
(BGI Research
BGI Research)
- Qianyue Ji
(MGI Tech)
- Liang Meng
(BGI Research
BGI Research)
- Rui Wang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Yuyan Liu
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Kaiqiang Liu
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Qian Wang
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
- Inge Seim
(Nanjing Normal University
Queensland University of Technology)
- Jun Zou
(Shanghai Ocean University)
- Guangyi Fan
(BGI Research
BGI Research
BGI Research)
- Shanshan Liu
(MGI Tech)
- Changwei Shao
(Chinese Academy of Fishery Sciences
Qingdao Marine Science and Technology Center)
Abstract
Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function and susceptibility to disease. Adaptive immunity is a shared trait of the common ancestor of cartilaginous and bony fishes. However, evolutionary features of lymphocytes in these two jawed vertebrates remain unclear. Here, we present a single-cell RNA sequencing atlas of immune cells from cartilaginous (white-spotted bamboo shark) and bony (zebrafish and Chinese tongue sole) fishes. Cross-species comparisons show that the same cell types across different species exhibit similar transcriptional profiles. In the bamboo shark, we identify a phagocytic B cell population expressing several pattern recognition receptors, as well as a T cell sub-cluster co-expressing both T and B cell markers. In contrast to a division by function in the bony fishes, we show close linkage and poor functional specialization among lymphocytes in the cartilaginous fish. Our cross-species single-cell comparison presents a resource for uncovering the origin and evolution of the gnathostome immune system.
Suggested Citation
Hong-Yan Wang & Jian-Yang Chen & Yanan Li & Xianghui Zhang & Xiang Liu & Yifang Lu & Hang He & Yubang Li & Hongxi Chen & Qun Liu & Yingyi Huang & Zhao Jia & Shuo Li & Yangqing Zhang & Shenglei Han & S, 2024.
"Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes,"
Nature Communications, Nature, vol. 15(1), pages 1-17, December.
Handle:
RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51761-4
DOI: 10.1038/s41467-024-51761-4
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