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Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2

Author

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  • Shan Nan Chen

    (Institute of Hydrobiology, Chinese Academy of Sciences
    Institute of Hydrobiology, Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Zhen Gan

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Jing Hou

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Yue Cong Yang

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Lin Huang

    (Institute of Hydrobiology, Chinese Academy of Sciences)

  • Bei Huang

    (Institute of Hydrobiology, Chinese Academy of Sciences
    Jimei University)

  • Su Wang

    (Pilot National Laboratory for Marine Science and Technology (Qingdao)
    Qingdao Agricultural University)

  • Pin Nie

    (Institute of Hydrobiology, Chinese Academy of Sciences
    Institute of Hydrobiology, Chinese Academy of Sciences
    Chinese Academy of Sciences
    Pilot National Laboratory for Marine Science and Technology (Qingdao))

Abstract

Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. Here we identify IFN-υ from the genomic sequences of vertebrates. The members of class II cytokine receptors, IFN-υR1 and IL-10R2, are identified as the receptor complex of IFN-υ, and are associated with IFN-υ stimulated gene expression and antiviral activity in zebrafish (Danio rerio) and African clawed frog (Xenopus laevis). IFN-υ and IFN-υR1 are separately located at unique and highly conserved loci, being distinct from all other three-type IFNs. IFN-υ and IFN-υR1 are phylogenetically clustered with class II cytokines and class II cytokine receptors, respectively. Therefore, the finding of this IFN ligand-receptor system may be considered as a type IV IFN, in addition to the currently recognized three types of IFNs in vertebrates.

Suggested Citation

  • Shan Nan Chen & Zhen Gan & Jing Hou & Yue Cong Yang & Lin Huang & Bei Huang & Su Wang & Pin Nie, 2022. "Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28645-6
    DOI: 10.1038/s41467-022-28645-6
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    1. Byrappa Venkatesh & Alison P. Lee & Vydianathan Ravi & Ashish K. Maurya & Michelle M. Lian & Jeremy B. Swann & Yuko Ohta & Martin F. Flajnik & Yoichi Sutoh & Masanori Kasahara & Shawn Hoon & Vamshidha, 2014. "Elephant shark genome provides unique insights into gnathostome evolution," Nature, Nature, vol. 505(7482), pages 174-179, January.
    2. Byrappa Venkatesh & Alison P. Lee & Vydianathan Ravi & Ashish K. Maurya & Michelle M. Lian & Jeremy B. Swann & Yuko Ohta & Martin F. Flajnik & Yoichi Sutoh & Masanori Kasahara & Shawn Hoon & Vamshidha, 2014. "Correction: Corrigendum: Elephant shark genome provides unique insights into gnathostome evolution," Nature, Nature, vol. 513(7519), pages 574-574, September.
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