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Sleep-like cortical dynamics during wakefulness and their network effects following brain injury

Author

Listed:
  • Marcello Massimini

    (University of Milan
    IRCCS Fondazione Don Carlo Gnocchi ONLUS)

  • Maurizio Corbetta

    (University of Padova
    Veneto Institute of Molecular Medicine (VIMM))

  • Maria V. Sanchez-Vives

    (Institut d’Investigacions Biomèdiques August Pi i Sunyer
    Institució Catalana de la Recerca i Estudis Avançats (ICREA))

  • Thomas Andrillon

    (CNRS
    Monash University)

  • Gustavo Deco

    (Institució Catalana de la Recerca i Estudis Avançats (ICREA)
    Computational Neuroscience Group)

  • Mario Rosanova

    (University of Milan)

  • Simone Sarasso

    (University of Milan)

Abstract

By connecting old and recent notions, different spatial scales, and research domains, we introduce a novel framework on the consequences of brain injury focusing on a key role of slow waves. We argue that the long-standing finding of EEG slow waves after brain injury reflects the intrusion of sleep-like cortical dynamics during wakefulness; we illustrate how these dynamics are generated and how they can lead to functional network disruption and behavioral impairment. Finally, we outline a scenario whereby post-injury slow waves can be modulated to reawaken parts of the brain that have fallen asleep to optimize rehabilitation strategies and promote recovery.

Suggested Citation

  • Marcello Massimini & Maurizio Corbetta & Maria V. Sanchez-Vives & Thomas Andrillon & Gustavo Deco & Mario Rosanova & Simone Sarasso, 2024. "Sleep-like cortical dynamics during wakefulness and their network effects following brain injury," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51586-1
    DOI: 10.1038/s41467-024-51586-1
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    References listed on IDEAS

    as
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