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Local sleep in awake rats

Author

Listed:
  • Vladyslav V. Vyazovskiy

    (University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard)

  • Umberto Olcese

    (University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard
    PERCRO Laboratory, Scuola Superiore Sant'Anna, 56217, Via Martiri, 11)

  • Erin C. Hanlon

    (University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard)

  • Yuval Nir

    (University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard)

  • Chiara Cirelli

    (University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard)

  • Giulio Tononi

    (University of Wisconsin-Madison, Madison, 6001 Research Park Boulevard)

Abstract

In an awake state, neurons in the cerebral cortex fire irregularly and electroencephalogram (EEG) recordings display low-amplitude, high-frequency fluctuations. During sleep, neurons oscillate between ‘on’ periods, when they fire as in an awake brain, and ‘off’ periods, when they stop firing altogether and the EEG displays high-amplitude slow waves. However, what happens to neuronal firing after a long period of being awake is not known. Here we show that in freely behaving rats after a long period in an awake state, cortical neurons can go briefly ‘offline’ as in sleep, accompanied by slow waves in the local EEG. Neurons often go offline in one cortical area but not in another, and during these periods of ‘local sleep’, the incidence of which increases with the duration of the awake state, rats are active and display an ‘awake’ EEG. However, they are progressively impaired in a sugar pellet reaching task. Thus, although both the EEG and behaviour indicate wakefulness, local populations of neurons in the cortex may be falling asleep, with negative consequences for performance.

Suggested Citation

  • Vladyslav V. Vyazovskiy & Umberto Olcese & Erin C. Hanlon & Yuval Nir & Chiara Cirelli & Giulio Tononi, 2011. "Local sleep in awake rats," Nature, Nature, vol. 472(7344), pages 443-447, April.
  • Handle: RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature10009
    DOI: 10.1038/nature10009
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    Citations

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    Cited by:

    1. Michael J Prerau & Katie E Hartnack & Gabriel Obregon-Henao & Aaron Sampson & Margaret Merlino & Karen Gannon & Matt T Bianchi & Jeffrey M Ellenbogen & Patrick L Purdon, 2014. "Tracking the Sleep Onset Process: An Empirical Model of Behavioral and Physiological Dynamics," PLOS Computational Biology, Public Library of Science, vol. 10(10), pages 1-19, October.
    2. Lukas L Imbach & Esther Werth & Ulf Kallweit & Johannes Sarnthein & Thomas E Scammell & Christian R Baumann, 2012. "Inter-Hemispheric Oscillations in Human Sleep," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-10, November.
    3. Mohamed Abdelhack & Peter Zhukovsky & Milos Milic & Shreyas Harita & Michael Wainberg & Shreejoy J. Tripathy & John D. Griffiths & Sean L. Hill & Daniel Felsky, 2023. "Opposing brain signatures of sleep in task-based and resting-state conditions," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Xu, Bang-Lin & Zhou, Jian-Fang & Li, Rui & Jiang, En-Hua & Yuan, Wu-Jie, 2023. "Neural dynamic transitions caused by changes of synaptic strength in heterogeneous networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 617(C).
    5. Marcello Massimini & Maurizio Corbetta & Maria V. Sanchez-Vives & Thomas Andrillon & Gustavo Deco & Mario Rosanova & Simone Sarasso, 2024. "Sleep-like cortical dynamics during wakefulness and their network effects following brain injury," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Gal Atlan & Noa Matosevich & Noa Peretz-Rivlin & Idit Marsh-Yvgi & Noam Zelinger & Eden Chen & Timna Kleinman & Noa Bleistein & Efrat Sheinbach & Maya Groysman & Yuval Nir & Ami Citri, 2024. "Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    7. Ziyue Wang & Xiang Fei & Xiaotong Liu & Yanjie Wang & Yue Hu & Wanling Peng & Ying-wei Wang & Siyu Zhang & Min Xu, 2022. "REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    8. Kazuhiro Kon & Koji L. Ode & Tomoyuki Mano & Hiroshi Fujishima & Riina R. Takahashi & Daisuke Tone & Chika Shimizu & Shinnosuke Shiono & Saori Yada & Kyoko Matsuzawa & Shota Y. Yoshida & Junko Yoshida, 2024. "Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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